2077164-48-6
Chemical Structure
CN-716 dihydrochloride
- CAS No.: 2077164-48-6
- Formula:C22H33BCl2N6O4
- Molecular Weight:527.25
IUPAC Name: ((R)-1-((S)-3-(4-(aminomethyl)phenyl)-2-benzamidopropanamido)-4-guanidinobutyl)boronic acid hydrochloride
InChIKey: FOGGTYQDBVHVJX-JYRWABTFSA-N
SMILES: NCC(C=C1)=CC=C1C[C@H](NC(C2=CC=CC=C2)=O)C(N[C@H](B(O)O)CCCNC(N)=N)=O.Cl.Cl
Biological Activity: CN-716 dihydrochloride is a reversible covalent flavivirus NS2B·NS3 protease inhibitor with antiviral activity. CN-716 dihydrochloride effectively inhibits the replication of dengue virus (DENV2), West Nile virus (WNV) and Zika virus (ZIKV). The IC50 values of CN-716 dihydrochloride against the proteases of the above three viruses are 0.066 μM, 0.11 μM and 0.25 μM, respectively, while the Ki values against the same proteases are 0.051 μM, 0.082 μM and 0.04 μM, respectively. CN-716 dihydrochloride can be used to study the infection mechanisms of dengue fever, West Nile fever and Zika virus infection[1][2].
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CN-716 dihydrochloride | CN-716 dihydrochloride is a reversible covalent flavivirus NS2B·NS3 protease inhibitor with antiviral activity. CN-716 dihydrochloride effectively inhibits the replication of dengue virus (DENV2), West Nile virus (WNV) and Zika virus (ZIKV). The IC50 values of CN-716 dihydrochloride against the proteases of the above three viruses are 0.066 μM, 0.11 μM and 0.25 μM, respectively, while the Ki values against the same proteases are 0.051 μM, 0.082 μM and 0.04 μM, respectively. CN-716 dihydrochloride can be used to study the infection mechanisms of dengue fever, West Nile fever and Zika virus infection. | |||||||||||||||||||||
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- [1]. Mahawaththa M C, et al. Solution conformations of a linked construct of the Zika virus NS2B-NS3 protease[J]. Antiviral research, 2017, 142: 141-147.
- [2]. Nitsche C, et al. Peptide-Boronic Acid Inhibitors of Flaviviral Proteases: Medicinal Chemistry and Structural Biology. J Med Chem. 2017;60(1):511-516. [Content Brief]
Keywords
