2. Disease Areas
  3. Metabolic or Endocrine Disease
  4. Gonadal Disease

Gonadal Disease

Gonadal disease refers to a group of disorders affecting the gonads, leading to abnormal sex hormone synthesis or action, with clinical manifestations including ambiguous genitalia, delayed puberty, infertility, erectile dysfunction, hypogonadism, and sexual dysfunction. These conditions may result from genetic mutations, hormonal imbalances, environmental factors, infections, or underlying medical issues, and are often associated with gonadal dysgenesis—a congenital disorder characterized by fibrous stromal replacement of gonadal tissue without germ cells. Diagnosis involves genetic testing, hormonal assessments, and imaging to evaluate reproductive function and related comorbidities.

 

Gonadal Disease (14):

Cat. No. 상품명 CAS No. Purity 화학구조
  • HY-B0742
    Hydroxyprogesterone caproate 630-56-8 99.29%
    Hydroxyprogesterone caproate (17α-Hydroxyprogesterone hexanoate; 17α-Hydroxyprogesterone caproate) is a progesterone receptor (progesterone receptor) ligand and steroid hormone transcription inhibitor. Hydroxyprogesterone caproate downregulates estrogen receptors in target tissues and activates their metabolic pathways, and exhibits equivalent affinity for progesterone receptor A and progesterone receptor B. Hydroxyprogesterone caproate shows no consistent teratogenicity or developmental toxicity in rat, mouse and monkey models, but induces resorption or abortion in rhesus monkeys at human-equivalent doses. Hydroxyprogesterone caproate promotes the production of TNF-α in lipopolysaccharide-stimulated whole blood from non-pregnant women. Hydroxyprogesterone caproate can be used in scientific research related to preterm birth.
    Hydroxyprogesterone caproate
  • HY-B0708
    β-Estradiol 17-acetate 1743-60-8 99.93%
    β-Estradiol 17-acetate (1,3,5(10)-Estratriene-3,17β-diol 17-acetate) is a long-acting endogenous estrogen precursor and also a cell viability and proliferation enhancer. β-Estradiol 17-acetate promotes the adhesion and proliferation of freshly isolated and revived female-derived human brain microvascular endothelial cells, and reverses the decreased viability of revived male-derived human brain microvascular endothelial cells. β-Estradiol 17-acetate exerts the microvascular protective effect of estrogen, enabling non-tumor human brain microvascular endothelial cells to be cultured in vitro for 2 months after cryopreservation. β-Estradiol 17-acetate is biotransformed into β-estradiol via hydrolase action in the in vitro skin of humans, hairless dogs, rats and hairless mice.
    β-Estradiol 17-acetate
  • HY-W036120
    Benzophenone-2 131-55-5 99.66%
    Benzophenone-2 (2,2',4,4'-Tetrahydroxybenzophenone) is an organic ultraviolet absorber that is widely used in personal care products and industrial products such as plastics and coatings. Benzophenone-2 is an endocrine disruptor that can interfere with estrogen receptors (ERα receptor) and pregnane X receptor (PXR receptor) activity, leading to reproductive toxicity, immune disorders, and metabolic abnormalities. Benzophenone-2 can inhibit the activity of α-glucosidase (IC50 = 49.72 μM), and can be used for research on diabetes.
    Benzophenone-2
  • HY-W094517
    Sodium phosphate dibasic heptahydrate 7782-85-6 98.74%
    Sodium phosphate dibasic heptahydrate is an orally active and osmotic laxative, often used as a component of over-the-counter gastrointestinal lavage drugs. Sodium phosphate dibasic heptahydrate draws water into the intestinal lumen, maintains electrical neutrality by retaining cations in the intestinal lumen, and thereby alters fecal volume, consistency and phosphate levels. Sodium phosphate dibasic heptahydrate can be used to generate self-assembled calcium phosphate tubular scaffolds, which support the adhesion, survival and elongation of mesenchymal stem cells. Sodium phosphate dibasic heptahydrate can be applied to research on factitious disorders and related fields.
    Sodium phosphate dibasic heptahydrate
  • HY-B1353
    Paroxypropione 70-70-2 99.97%
    Paroxypropione (4'-Hydroxypropiophenone) is a manufactured, nonsteroidal estrogen and can be used for endocrine research.
    Paroxypropione
  • HY-W099803
    (Z)-11-Hexadecenyl acetate 34010-21-4
    (Z)-11-Hexadecenyl acetate is a component of insect sex pheromones, which elicits electroantennogram responses in male Plutella xylostella and induces their wing-fanning and claspers-exposing behaviors. (Z)-11-Hexadecenyl acetate also serves as a sex pheromone component of Spodoptera exigua and Chilo suppressalis. When used in combination with other pheromones, (Z)-11-Hexadecenyl acetate significantly enhances the attraction effect on male Tryporyza incertulas, and it exists in trace amounts in the eluate of the ovipositor of female Tryporyza incertulas. (Z)-11-Hexadecenyl acetate shows no attraction effect on male Cnaphalocrocis medinalis and exhibits species specificity.
    (Z)-11-Hexadecenyl acetate
  • HY-19689
    Ipidacrine hydrochloride 90043-86-0
    Ipidacrine (NIK-247; Amiridine) hydrochloride is orally active and blood-brain-barrier-penetrant AChE and BuChE inhibitors with IC50 values of 1 μM and 1.9 μM, respectively, which is also a partial agonist of M2-cholinergic receptors and a reversible cholinesterase inhibitor. Ipidacrine hydrochloride has a stimulating effect on neuromuscular transmission and excitation along the nerve fibres with a moderately anti-pain effect. Ipidacrine hydrochloride is an aminopyridines and is structurally similar to Tacrine (HY-111338). Ipidacrine hydrochloride is effective in various amnesia models, improves erectile function and inhibits K+ and Na+-channels in the neuronal membrane in diabetic rats. Ipidacrine hydrochloride is promising for research of Alzheimer’s disease, ischaemic stroke, idiopathic neuropathy of the facial nerve, diabetes mellitus-induced erectile dysfunction and other deficits in central or peripheral cholinergic deseases.
    Ipidacrine hydrochloride
  • HY-123579
    Androgen receptor ligand 4 92071-89-1
    Androgen receptor ligand 4 (Compound MDG486) is an androgen receptor ligand with an IC50 of >100 µM. Androgen receptor ligand 4 can be used in the research of adolescent development.
    Androgen receptor ligand 4
  • HY-W073128
    Perfluorotetradecanoic acid 376-06-7 98.0%
    Perfluorotetradecanoic acid (PFTeDA) is an orally active perfluoroalkyl substance. Perfluorotetradecanoic acid directly binds to the ligand-binding domain of purified hPPARγ, with a Kd value of 157.8 μM. Perfluorotetradecanoic acid significantly reduces the activity of the SIRT1/PGC1α and AMPK signaling pathways while stimulating the activity of the AKT1/mTOR signaling pathway. Perfluorotetradecanoic acid significantly upregulates the expression of corticosterone biosynthesis genes. Perfluorotetradecanoic acid increases ROS levels and promotes Apoptosis. Perfluorotetradecanoic acid impairs Leydig cell function and male reproductive endocrine function in adult male rats.
    Perfluorotetradecanoic acid
  • HY-P11738
    Murine ZP3 peptide (330-342) 152439-29-7 98.76%
    Murine ZP3 peptide (330-342) is a zona pellucida 3 polypeptide fragment with the amino acid sequence NSSSSQFQIHGPR. Murine ZP3 peptide (330-342) induces autoimmune premature ovarian failure (POF). Murine ZP3 peptide (330-342) can be used for the research of premature ovarian failure.
    Murine ZP3 peptide (330-342)
  • HY-180410
    YM-1758735 262294-30-4
    YM-1758735 is an orally active androgen receptor (AR) antagonist with an IC50 of 0.2 μM. YM-1758735 inhibits AR-mediated transcriptional activation. YM-1758735 can be used for the research of prostate.
    YM-1758735
  • HY-131531B
    (R)-5-OH-DPAT 69367-51-7
    (R)-5-OH-DPAT ((R)-5-Hydroxy-DPAT) is the R-enantiomer of 5-OH-DPAT (HY-131531A). 5-OH-DPAT is a weak antagonist of the dopamine D2 receptor (dopamine D2-receptor). 5-OH-DPAT moderately promotes sexual behavior in male rats.
    (R)-5-OH-DPAT
  • HY-106614
    Osaterone acetate 105149-00-6
    Osaterone acetate is an orally active steroid anti-androgen agent, mainly used for benign prostatic hyperplasia (BPH) in dogs. Osaterone acetate competitively antagonizes androgen receptor and inhibits 5α-reductase, reducing the concentration of dihydrotestosterone (DHT) while blocking the growth-stimulating effects of testosterone and DHT on prostate cells. Osaterone acetate can rapidly alleviate the symptoms of BPH in dogs without affecting the fertility of breeding dogs.
    Osaterone acetate
  • HY-178792
    TGI-15 3073601-32-5
    TGI-15 is a highly selective prostaglandin F receptor antagonist. TGI-15 inhibits downstream signaling pathways by blocking the binding of PGF2 α to FP receptors. TGI-15 can be used for research on fibrotic and inflammatory conditions.
    TGI-15