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Cat. No.: HY-180410

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YM-1758735

YM-1758735 is an orally active androgen receptor (AR) antagonist with an IC₅₀ of 0.2 μM. YM-1758735 inhibits AR-mediated transcriptional activation. YM-1758735 can be used for the research of prostate.

For research use only. We do not sell to patients.

CAS No.: 262294-30-4
Formula: C₂₁H₁₉F₅N₄O
Molecular Weight:438.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

YM-1758735 Chemical Structure

CAS No.: 262294-30-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

YM-1758735 (Compound 85) inhibits AR-mediated transcriptional activation with an IC₅₀ of 0.2 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

YM-1758735 (Compound 85) (10 mg/kg; p.o.; daily; 15 days) does not reduce ventral prostate weight in male Wistar rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar (male)^[1]
Dosage:

10 mg/kg
Administration:

p.o.; daily; 15 days
Result:

Failed to decrease ventral prostate weight.

Chemical Information

CAS No. 262294-30-4
Molecular Weight 438.40
Formula C₂₁H₁₉F₅N₄O
SMILES

C[C@@H]1N(C2=CC(C(F)(F)F)=C(C#N)C=C2)C[C@@H](C)N(C(NC3=C(F)C=C(F)C=C3)=O)C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xiang W, et al. Therapeutic Strategies to Target the Androgen Receptor. J Med Chem. 2022;65(13):8772-8797. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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