DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium hydrate  (Synonyms: HMG-CoA disodium hydrate)

DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium hydrate is a disodium salt compound of HMG-CoA, is a intermediate of terpenes and ketone bodies. DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium also involves in ester metabolism in vivo, as a precursor for cholesterol synthesis, and regulates cholesterol synthesis by coupling LDL receptor^[1][2].

DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium hydrate comes from acetyl-coa and acetyl-CoA converted from HMG-CoA synthetase, mainly dependents on oxidative reactions in mitochondria^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

C₂₇H₄₄N₇Na₂O₂₁P₃S.xH₂O

103476-21-7

Solid

White to off-white

O[C@@H]1[C@H](OP(O)(O)=O)[C@H](O[C@H]1N2C(N=CN=C3N)=C3N=C2)COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(CC(C)(O)CC(O)=O)=O)=O)=O)(O[Na])=O)(O[Na])=O.[x].O

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Millán Núñez-Cortés J, et al. Fármacos hipolipemiantes y PCSK9 [Lipid-lowering drugs and PCSK9]. Clin Investig Arterioscler. 2016 May;28 Suppl 2:9-13. Spanish.  [Content Brief]

  [2]. Wang Wei, er al. The Key Enzyme of Cholesterol Synthesis Pathway:HMG CoA Reductase and Disease. PROGRESS IN PHYSIOLOGICAL SCIENCES. 1999. (01):7-11.