2. Antibody-drug Conjugate/ADC Related Neuronal Signaling GPCR/G Protein
  3. Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor
  4. DOTA-LM3

DOTA-LM3 is a somatostatin receptor (SSTR) antagonist. LM3 refers to p-Cl-Phe- cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr- NH2, as well as a somatostatin antagonist. DOTA-LM3 is often isotopically labeled for tracing tumors in vivo, such as 177Lu-DOTA-LM3 and 68 Ga-DOTA-LM3. 68 Ga-DOTA-LM3 shows favorable biodistribution, high tumor uptake, good tumor retention, and few safety concerns. 177Lu-DOTA-LM3 can be used for research in DOTATOC-negative liver metastases, such as pancreatic NET and extensive tumor thrombosis. DOTA-LM3 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

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DOTA-LM3

DOTA-LM3 構造式

CAS 番号 : 1192362-32-5

容量 価格（税別） 在庫状況 数量
5 mg $320 在庫あり
10 mg $500 在庫あり
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100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 2 publication(s) in Google Scholar

Other Forms of DOTA-LM3:

DOTA-LM3 関連抗体

Top Publications Citing Use of Products

Radionuclide-Drug Conjugates (RDCs) アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
RDC Peptide RDC Antibody RDC Bifunctional Chelator RDC Linker Other

Somatostatin Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
SSTR1 SSTR2 SSTR3 SSTR5 SSTR4

  • 生物活性

  • 純度とドキュメンテーション

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製品説明

DOTA-LM3 is a somatostatin receptor (SSTR) antagonist. LM3 refers to p-Cl-Phe- cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr- NH2, as well as a somatostatin antagonist. DOTA-LM3 is often isotopically labeled for tracing tumors in vivo, such as 177Lu-DOTA-LM3 and 68 Ga-DOTA-LM3. 68 Ga-DOTA-LM3 shows favorable biodistribution, high tumor uptake, good tumor retention, and few safety concerns. 177Lu-DOTA-LM3 can be used for research in DOTATOC-negative liver metastases, such as pancreatic NET and extensive tumor thrombosis[1][2]. DOTA-LM3 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

IC50 & Target

RDC Peptide

 

体外実験

177Lu-DOTA-LM3 is tolerated. 177Lu-DOTA-LM3 in the whole body and in the kidneys, spleen, and metastases, resulting in higher mean absorbed organ and tumor doses[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DOTA-LM3 関連抗体
臨床実験
分子量

1550.16

分子式

C69H93ClN16O19S2
CAS 番号
Appearance

Solid

Color

White to off-white

Sequence

DOTA-[p-Cl-Phe-cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr-NH2]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

polypeptide, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (polypeptide, sealed storage, away from moisture and light)
溶剤 & 溶解度
体外: 

H2O : ≥ 100 mg/mL (64.51 mM)

DMSO : 50 mg/mL (32.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6451 mL 3.2255 mL 6.4509 mL
5 mM 0.1290 mL 0.6451 mL 1.2902 mL
10 mM 0.0645 mL 0.3225 mL 0.6451 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体積 （開始）

V1

=
濃度 （終了）

C2

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体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 0.6451 mL 3.2255 mL 6.4509 mL 16.1274 mL
5 mM 0.1290 mL 0.6451 mL 1.2902 mL 3.2255 mL
10 mM 0.0645 mL 0.3225 mL 0.6451 mL 1.6127 mL
15 mM 0.0430 mL 0.2150 mL 0.4301 mL 1.0752 mL
20 mM 0.0323 mL 0.1613 mL 0.3225 mL 0.8064 mL
25 mM 0.0258 mL 0.1290 mL 0.2580 mL 0.6451 mL
30 mM 0.0215 mL 0.1075 mL 0.2150 mL 0.5376 mL
H2O 40 mM 0.0161 mL 0.0806 mL 0.1613 mL 0.4032 mL
50 mM 0.0129 mL 0.0645 mL 0.1290 mL 0.3225 mL
60 mM 0.0108 mL 0.0538 mL 0.1075 mL 0.2688 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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DOTA-LM3 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DOTA-LM31192362-32-5Radionuclide-Drug Conjugates (RDCs)Somatostatin ReceptorSSTRsSSTRsomatostatin receptorLM3p-Cl-Phe- cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr- NH2sotopically labeled177Lu-DOTA-LM368 Ga-DOTA-LM3biodistributionhigh tumor uptakegood tumor retentionsafetyDOTATOC-negative liver metastasespancreatic NETextensive tumor thrombosisInhibitorinhibitorinhibit

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製品名:
DOTA-LM3
製品番号:
HY-P5126
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