Epothilone C 

Epothilone C is a polyketide natural product. Epothilone C is produced by the combined action of one nonribosomal peptide synthetase (NRPS) and nine polyketide synthase (PKS) modules in a multienzyme system. Epothilone C can be used for tumor research^[1][2][3].

477.66

C₂₆H₃₉NO₅S

186692-73-9

Solid

O=C(C[C@H](O)C1(C)C)O[C@H](/C(C)=C/C2=CSC(C)=N2)C/C=C\CCC[C@H](C)[C@H](O)[C@@H](C)C1=O

Room temperature in continental US; may vary elsewhere.

• [1]. Chen H, et al. Epothilone biosynthesis: assembly of the methylthiazolylcarboxy starter unit on the EpoB subunit. Chem Biol. 2001 Sep;8(9):899-912.  [Content Brief]

  [2]. Mutka SC, et al. Heterologous production of epothilone C and D in Escherichia coli. Biochemistry. 2006 Jan 31;45(4):1321-30.  [Content Brief]

  [3]. Boddy CN, et al. Epothilone C macrolactonization and hydrolysis are catalyzed by the isolated thioesterase domain of epothilone polyketide synthase. J Am Chem Soc. 2003 Mar 26;125(12):3428-9. Boddy CN, et al. Epothilone C macrolactonization and hydrolysis are catalyzed by the isolated thioesterase domain of epothilone polyketide synthase. J Am Chem Soc. 2003 Mar 26;125(12):3428-9.  [Content Brief]