186692-73-9
186692-73-9
Chemical Structure
Epothilone C
- CAS. Nr.: 186692-73-9
- Formula:C26H39NO5S
- Molecular Weight:477.66
IUPAC Name: (4S,7R,8S,9S,16S,Z)-4,8-dihydroxy-5,5,7,9-tetramethyl-16-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)oxacyclohexadec-13-ene-2,6-dione
InChIKey: BEFZAMRWPCMWFJ-QJKGZULSSA-N
SMILES: O=C(C[C@H](O)C1(C)C)O[C@H](/C(C)=C/C2=CSC(C)=N2)C/C=C\CCC[C@H](C)[C@H](O)[C@@H](C)C1=O
Biological Activity: Epothilone C is a polyketide natural product. Epothilone C is produced by the combined action of one nonribosomal peptide synthetase (NRPS) and nine polyketide synthase (PKS) modules in a multienzyme system. Epothilone C can be used for tumor research[1][2][3].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Epothilone C | 98.53% | Epothilone C is a polyketide natural product. Epothilone C is produced by the combined action of one nonribosomal peptide synthetase (NRPS) and nine polyketide synthase (PKS) modules in a multienzyme system. Epothilone C can be used for tumor research. | ||||||||||||||||||||
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References
- [1]. Chen H, et al. Epothilone biosynthesis: assembly of the methylthiazolylcarboxy starter unit on the EpoB subunit. Chem Biol. 2001 Sep;8(9):899-912. [Content Brief]
- [2]. Mutka SC, et al. Heterologous production of epothilone C and D in Escherichia coli. Biochemistry. 2006 Jan 31;45(4):1321-30. [Content Brief]
- [3]. Boddy CN, et al. Epothilone C macrolactonization and hydrolysis are catalyzed by the isolated thioesterase domain of epothilone polyketide synthase. J Am Chem Soc. 2003 Mar 26;125(12):3428-9. Boddy CN, et al. Epothilone C macrolactonization and hydrolysis are catalyzed by the isolated thioesterase domain of epothilone polyketide synthase. J Am Chem Soc. 2003 Mar 26;125(12):3428-9. [Content Brief]
