Flutropium bromide  (Synonyms: Ba 598Br; Flubron)

Flutropium bromide (Ba 598Br) is a organic bromide salt of flutropium. Flutropium bromide shows an anticholinergic effect. Flutropium bromide effectively suppresses spasms and it can be used for the research of asthma and chronic obstructive pulmonary disease^[1][2][3].

Flutropium bromide is more effective than atropine in vitro experiments^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Flutropium bromide (0.0003%; single inhalation) inhibits the acetylcholine induced bronchoconstriction without changing the fall in blood pressure in guinea pigs^[1].
Flutropium bromide (3 and 10 mg/kg; i.v.) shows a weak mast cell stabilizing action, but no antagonistic action against LTD4 and serotonin^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

478.39

C₂₄H₂₉BrFNO₃

63516-07-4

FCC[N@@+]([C@@H](CC1)C2)(C)[C@H]1C[C@@H]2OC(C(C3=CC=CC=C3)(C4=CC=CC=C4)O)=O.[Br-]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Mizuno H, et al. [Effects of flutropium bromide, a new anti-asthma drug, alone or in combination with salbutamol, aminophylline and disodium cromoglycate on the acetylcholine induced bronchoconstriction]. Nihon Yakurigaku Zasshi. 1990 Jan;95(1):31-40.  [Content Brief]

  [2]. Misawa M, et al. [Effects of flutropium bromide, a new antiasthma drug, on mediator release from mast cells and actions of mediators]. Nihon Yakurigaku Zasshi. 1988 Feb;91(2):97-103. Japanese.  [Content Brief]

  [3]. Bauer R, Fügner A. Pharmacology of the anticholinergic bronchospasmolytic agent flutropium bromide. Arzneimittelforschung. 1986 Sep;36(9):1348-52.  [Content Brief]