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  2. FR901464


Cat. No.: HY-16212
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FR901464 is a potent spliceosome inhibitor with prominent anti-tumor and anti-cancer effects.

For research use only. We do not sell to patients.

FR901464 Chemical Structure

FR901464 Chemical Structure

CAS No. : 146478-72-0

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FR901464 is a potent spliceosome inhibitor with prominent anti-tumor and anti-cancer effects[1].

In Vitro

FR901464 (10-20 ng/ml; 6-24 hours) inhibits the growth of murine solid tumors, Colon 38 carcinoma and Meth A fibrosarcoma. FR901464 induces characteristic G1 and G2/M phase arrest in the cell cycle and internucleosomal degradation of genomic DNA with the same kinetics as activation of SV40 promoter-dependent cellular transcription in M-8 tumor cells[1].
FR901464 (1-10 ng/ml; 16 hours) suppresses the transcription of some inducible endogenous genes but not house keeping genes in M-8 cells[1].
FR901464 exhibits potent anticancer activity. It shows enhancement of activity of a promoter of the SV40 DNA tumor virus at 10 nM concentration in M-8 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight





Room temperature in continental US; may vary elsewhere.


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