2. Neuronal Signaling GPCR/G Protein
  3. Amyloid-β mAChR Cholinesterase (ChE)
  4. Fustin

Fustin  (Synonyms: (±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone)

製品番号: HY-N8376 純度: 99.6%
COA 取扱説明書 Technical Support

Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) is a potent amyloid β (Aβ) inhibitor. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases the expression of acetylcholine (ACh) levels, choline acetyltransferase (ChAT) activity, and ChAT gene induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) decreases in acetyl cholinesterase (AChE) activity and AChE gene expression induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases muscarinic M1 receptor gene expression and muscarinic M1 receptor binding activity. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) can be used for Alzheimer's disease research.

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Fustin

Fustin 構造式

CAS 番号 : 20725-03-5

容量 価格（税別） 在庫状況 数量
1 mg $75 在庫あり
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10 mg   お問い合わせ  

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Fustin 関連抗体

Top Publications Citing Use of Products

mAChR アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

Cholinesterase (ChE) アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
AChE BChE

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製品説明

Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) is a potent amyloid β (Aβ) inhibitor. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases the expression of acetylcholine (ACh) levels, choline acetyltransferase (ChAT) activity, and ChAT gene induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) decreases in acetyl cholinesterase (AChE) activity and AChE gene expression induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases muscarinic M1 receptor gene expression and muscarinic M1 receptor binding activity. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) can be used for Alzheimer's disease research[1].

Cellular Effect
Cell Line Type Value Description References
K562 IC50
>100 μg/mL
Compound: 21
Cytotoxicity in human K562 cells by SRB assay
Cytotoxicity in human K562 cells by SRB assay
[PMID: 28793973]
体内実験

Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) (50-100 mg/kg; p.o.; daily, for 11days; Aβ-treated C57BL/6 mice) attenuates Aβ (1-42)-induced impairments in conditioned fear learning and passive avoidance behavior[1].
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) (50-100 mg/kg; p.o.; daily, for 11days; Aβ-treated C57BL/6 mice) alters Aβ (1-42)-induced changes in ACh level and AChE and ChAT activity and gene expression[1].
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) (50-100 mg/kg; p.o.; daily, for 11days; Aβ-treated C57BL/6 mice) increases Aβ (1-42)-induced reduction in M1 receptor mRNA and protein expression in Aβ-treated C57BL/6 mice. Fustin increases p-ERK and p-CREB expression in Aβ-treated C57BL/6 mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Aβ-treated C57BL/6 mice[1]
Dosage: 50 and 100 mg/kg
Administration: Oral administration;daily, for 11days
Result: Decreased freezing response in Aβ-treated C57BL/6 mice.
Animal Model: Aβ-treated C57BL/6 mice[1]
Dosage: 50 and 100 mg/kg
Administration: Oral administration;daily, for 11days
Result: Increased the expression of Ach, ChAT gene and ChAT activity. Decreased the expression of AChE gene and AChE activity.
Animal Model: Aβ-treated C57BL/6 mice[1]
Dosage: 50 and 100 mg/kg
Administration: Oral administration;daily, for 11days
Result: Increased gene expression of M2- , M3- ,M4-, M5-, α4β, α7-receptor, p-ERK and p-CREB.
分子量

288.25

分子式

C15H12O6
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

OC1=CC([C@H]2OC3=CC(O)=CC=C3C([C@@H]2O)=O)=CC=C1O
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (346.92 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4692 mL 17.3461 mL 34.6921 mL
5 mM 0.6938 mL 3.4692 mL 6.9384 mL
10 mM 0.3469 mL 1.7346 mL 3.4692 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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純度とドキュメンテーション

純度: 99.6%

COA (249 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4692 mL 17.3461 mL 34.6921 mL 86.7303 mL
5 mM 0.6938 mL 3.4692 mL 6.9384 mL 17.3461 mL
10 mM 0.3469 mL 1.7346 mL 3.4692 mL 8.6730 mL
15 mM 0.2313 mL 1.1564 mL 2.3128 mL 5.7820 mL
20 mM 0.1735 mL 0.8673 mL 1.7346 mL 4.3365 mL
25 mM 0.1388 mL 0.6938 mL 1.3877 mL 3.4692 mL
30 mM 0.1156 mL 0.5782 mL 1.1564 mL 2.8910 mL
40 mM 0.0867 mL 0.4337 mL 0.8673 mL 2.1683 mL
50 mM 0.0694 mL 0.3469 mL 0.6938 mL 1.7346 mL
60 mM 0.0578 mL 0.2891 mL 0.5782 mL 1.4455 mL
80 mM 0.0434 mL 0.2168 mL 0.4337 mL 1.0841 mL
100 mM 0.0347 mL 0.1735 mL 0.3469 mL 0.8673 mL
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Fustin Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fustin20725-03-5(±)-Fustin 3,7,3',4'-TetrahydroxyflavanoneAmyloid-βmAChRCholinesterase (ChE)β-amyloid peptideAβAbetaMuscarinic acetylcholine receptorAchChATAChEmuscarinic M1 receptor genemuscarinic M1 receptor bindingAlzheimerInhibitorinhibitorinhibit

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