2. TGF-beta/Smad
  3. TGF-β Receptor
  4. Garetosmab

Garetosmab  (Synonyms: REGN 2477)

Art. -Nr.: HY-P99632 Reinheit: 99.57%
COA
SDS
Technical Support

Garetosmab (REGN 2477) is a fully human IgG4 monoclonal antibody that specifically inhibits activin A. Garetosmab can be used for fibrodysplasia ossificans progressiva (FOP) research.

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CAS. Nr. : 2097125-54-5

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Based on 1 publication(s) in Google Scholar

Garetosmab Spezialitätsempfehlungen:

Garetosmab Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Garetosmab

Alle TGF-β Receptor Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
ALK1 ALK2 ALK3 ALK4 ALK5 ALK6 ALK7 TGFβR2 ACVR2A ACVR2B BMP GDF15

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Beschreibung

Garetosmab (REGN 2477) is a fully human IgG4 monoclonal antibody that specifically inhibits activin A. Garetosmab can be used for fibrodysplasia ossificans progressiva (FOP) research[1].

Isotype

Human IgG4 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

INHBA/Activin A
In Vitro

Garetosmab (REGN 2477) specifically binds to and blocks signaling of activin proteins containing the inhibin βα subunit (activins A, AB, and AC). In vitro, Garetosmab has high affinity and specificity for activins A, AB, and AC, but does not bind or functionally inhibit other TGF-β family ligands that share the same activin receptor pathways, including activin B, inhibin A, BMP-2, BMP6, BMP9, BMP10, GDF8, and GDF11[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Garetosmab Related Antibodies
Klinische Studie
Gene ID

3624  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molekulargewicht

145.52 kDa

CAS. Nr.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Garetosmab]
Versand

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
Biological Activity
  • Immobilized Human Latent Activin A/INHBA Protein, His Tag can bind Garetosmab. The EC50 for this effect is 15.03 ng/mL.
Reinheit & Dokumentation

Purity: 99.57%

SDS (251 KB)

COA (232 KB) SDS-PAGE (81 KB) SEC-HPLC (224 KB)

Inhibitory Antibodies User Guide (603 KB)
Verweise
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Garetosmab Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Garetosmab2097125-54-5REGN 2477REGN2477REGN-2477TGF-β ReceptorTransforming growth factor beta receptorsActivin Ahuman IgG4 monoclonal antibodyfibrodysplasia ossificans progressiva,Inhibitorinhibitorinhibit

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