2. NF-κB Immunology/Inflammation
  3. NF-κB NO Synthase
  4. Human serum albumin

Human serum albumin  (Synonyms: HSA; アルブミン ヒト血清由来; HSA アルブミン)

製品番号: HY-P1956 純度: 99.9%
COA 取扱説明書 Technical Support

Human serum albumin (HSA) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. Human serum albumin exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. Human serum albumin can block the inhibitory effect of GML on human T cells, providing protective function for T cells. Human serum albumin is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-κB, NF-κB, and peroxynitrite (ONOO−) in the vascular wall, contributing to the reduction of blood pressure.
This product is recombinant Human Serum Albumin expressed in a microbial expression system.

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CAS 番号 : 70024-90-7

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>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
100 mg $50 在庫あり
250 mg $100 在庫あり
500 mg $150 在庫あり
1 g $250 在庫あり
5 g $750 在庫あり
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Based on 4 publication(s) in Google Scholar

Human serum albumin 関連抗体

Top Publications Citing Use of Products

    Human serum albumin purchased from MedChemExpress. Usage Cited in: Cell Rep. 2023 Nov 23;42(12):113472.  [Abstract]

    The fluorescent response of mtGLP to cholesterol, triglyceride and Human serum albumin (HSA). Emission spectra of mtGLP to DOPC (40 μg/mL) in the presence of HSA (80 μg/mL), cholesterol(80μg/mL) and triglyceride (80 μg/mL) in 10.0 mM Tris-HCl buffer (pH 7.4,100.0 mMK+) with excitationatλex=405 nm.

    NF-κB アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

    NO Synthase アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    nNOS iNOS eNOS

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    製品説明

    Human serum albumin (HSA) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. Human serum albumin exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. Human serum albumin can block the inhibitory effect of GML on human T cells, providing protective function for T cells. Human serum albumin is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-κB, NF-κB, and peroxynitrite (ONOO−) in the vascular wall, contributing to the reduction of blood pressure[1][2][3].
    This product is recombinant Human Serum Albumin expressed in a microbial expression system.

    IC50 & Target

    iNOS

     

    体外実験

    HAS (5 μM, 0-90 minutes) can bind with Glycerol Monolaurate (GML), with a Kd value of 1.4 μM. HSA can prevent the ability of GML to inhibit human T cells and protect the function of T cells[3].
    HSA (0.01, 0.05, 0.1 μM, 0-24 h) alleviates the GML-induced phosphorylation of AKT at threonine 308 and serine 473 residues as well as the formation of LAT, PLC-γ1, and AKT microclusters, and restores the production of IFN-γ, IL-2, IL-10, and TNF-α in GML-treated cells[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Human serum albumin 関連抗体

    Western Blot Analysis[3]

    Cell Line: Activate peripheral blood T cells
    Concentration: 0.05 μM
    Incubation Time: 0, 2, 5, 15 min
    Result: Affected the ability of GML to inhibit AKT phosphorylation.

    RT-PCR[3]

    Cell Line: Activate peripheral blood T cells
    Concentration: 0.1, 0.05, 0.005 μM
    Incubation Time: 24h
    Result: Restored the production of IFN-γ, IL-2, IL-10, and TNF-α in GML treated cells.
    体内実験

    Human serum albumin (10 ml/kg; Intravenous injection; Once at 1 hour and once at 5 hours; twice) partially prevents the oxidative stress induced by LPS (HY-D1056) (50 mg/kg) in male Swiss mouse models, as well as the decrease in blood pressure due to upregulation of NF-κB, iNOS, and peroxynitrite (ONOO−) in the vascular wall[4].
    Human serum albumin (10 ml/kg; Intravenous injection; Once at 1 hour and once at 5 hours; twice) in a Male Swiss mouse model completely prevented endotoxin-induced reduced vascular response to phenol catecholamines, electromyotonia, and endothelial dysfunction, and reduced inflammatory processes leading to oxidative and nitrite stress and reduced vascular reactivity[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male Swiss mouse models[4]
    Dosage: 10 ml/kg; Once at 1 hour and once at 5 hours; twice
    Administration: HSA: Intravenous injection; LPS: Intraperitoneal injection (i.p.), 50 mg/kg
    Result: Prevented LPS-induced tissue NO overproduction and increased iNOS expression.
    Was effective in reducing LPS-induced oxidative stress.
    Alleviated this LPS-induced oxidative stress and inhibited the formation of peroxynitrite (ONOO−).
    Reduced LPS-induced upregulation of NF-κB.
    臨床実験
    CAS 番号
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    [Human serum albumin]
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    -20°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    溶剤 & 溶解度
    体外: 

    H2O : ≥ 100 mg/mL

    *"≥" means soluble, but saturation unknown.

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    純度とドキュメンテーション

    純度: 99.9%

    COA (230 KB)

    取扱説明書 (2659 KB)
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    Human serum albumin Related Classifications

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      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Human serum albumin70024-90-7HSANF-κBNO SynthaseNuclear factor-κBNuclear factor-kappaBNitric oxide synthasesNOSGlycerol monolaurateNF-KBVascularEndothelialAntioxidantAnticoagulantAnti-inflammatoryCardiovascularInhibitorinhibitorinhibit

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    製品番号:
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