Hydroxypinacolone retinoate (Synonyms: HPR)

Art. -Nr.: HY-W442049 Reinheit: 99.33%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Hydroxypinacolone retinoate (HPR) is a retinol derivative, which binds directly with retinoic acid receptors (RARs). Hydroxypinacolone retinoate, when used in combination with Retinyl propionate, can be used in anti-skin aging research.

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Hydroxypinacolone retinoate Chemische Struktur

CAS. Nr. : 893412-73-2

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	Auf Lager	Estimated Time of Arrival: December 31
Solid
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
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Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle RAR/RXR Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

RXRα RXRβ RXRγ

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

Klinische Studie

Molekulargewicht

398.58

Formel

C₂₆H₃₈O₃

CAS. Nr.

893412-73-2

Appearance

Solid

Color

White to yellow

SMILES

CC(C)(C)C(COC(/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)=O)=O

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 12.5 mg/mL (31.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 12.5 mg/mL (31.36 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5089 mL	12.5445 mL	25.0891 mL
5 mM	0.5018 mL	2.5089 mL	5.0178 mL
10 mM	0.2509 mL	1.2545 mL	2.5089 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (3.14 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Reinheit & Dokumentation

Purity: 99.33%

Select Batch:

Data Sheet (267 KB) SDS (419 KB)

COA (242 KB) HNMR (174 KB) LCMS (104 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Wang Q, et al. The synergistic effect of retinyl propionate and hydroxypinacolone retinoate on skin aging. J Cosmet Dermatol. 2023 Jul;22(7):2040-2049. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / Ethanol	1 mM	2.5089 mL	12.5445 mL	25.0891 mL	62.7227 mL
	5 mM	0.5018 mL	2.5089 mL	5.0178 mL	12.5445 mL
	10 mM	0.2509 mL	1.2545 mL	2.5089 mL	6.2723 mL
	15 mM	0.1673 mL	0.8363 mL	1.6726 mL	4.1815 mL
	20 mM	0.1254 mL	0.6272 mL	1.2545 mL	3.1361 mL
	25 mM	0.1004 mL	0.5018 mL	1.0036 mL	2.5089 mL
	30 mM	0.0836 mL	0.4182 mL	0.8363 mL	2.0908 mL

Hydroxypinacolone retinoate Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hydroxypinacolone retinoate893412-73-2HPRRAR/RXRRetinoic acid receptorsRetinoid X receptorsretinol derivativeretinoic acid receptorsRetinyl propionateanti-skin agingInhibitorinhibitorinhibit

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Hydroxypinacolone retinoate (Synonyms: HPR)

Hydroxypinacolone retinoate Related Antibodies

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle RAR/RXR Isoform-spezifische Produkte anzeigen:

Biologische Aktivität

Reinheit & Dokumentation

Verweise

Kundenbewertung

Molaritätsrechner

Verdünnungsrechner