893412-73-2
Chemical Structure
Hydroxypinacolone retinoate
Synonym(s): HPR
- CAS No.: 893412-73-2
- Formula:C26H38O3
- Molecular Weight:398.58
IUPAC Name: tert-butyl 4-(methylamino)butanoate hydrochloride
InChIKey: XLPLFRLIWKRQFT-XUJYDZMUSA-N
SMILES: CC(C)(C)C(COC(/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)=O)=O
Biological Activity: Hydroxypinacolone retinoate (HPR) is a direct-binding agonist of retinoic acid receptor (RAR). Hydroxypinacolone retinoate has low irritation and high stability; when formulated into nanoparticles, its transdermal efficiency is enhanced, allowing it to penetrate deep into the dermis and achieve sustained release. When used in combination with Retinyl propionate, hydroxypinacolone retinoate promotes fibroblast proliferation and upregulates the gene expression of type IV collagen, CRBP-I and RARB. Hydroxypinacolone retinoate can be used in research related to skin wrinkles and skin aging[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Hydroxypinacolone retinoate | 99.33% | Hydroxypinacolone retinoate (HPR) is a direct-binding agonist of retinoic acid receptor (RAR). Hydroxypinacolone retinoate has low irritation and high stability; when formulated into nanoparticles, its transdermal efficiency is enhanced, allowing it to penetrate deep into the dermis and achieve sustained release. When used in combination with Retinyl propionate, hydroxypinacolone retinoate promotes fibroblast proliferation and upregulates the gene expression of type IV collagen, CRBP-I and RARB. Hydroxypinacolone retinoate can be used in research related to skin wrinkles and skin aging. | ||||||||||||||||||||
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- [1]. Bai D, et al. High Stability and Low Irritation of Retinol Propionate and Hydroxypinacolone Retinoate Supramolecular Nanoparticles with Effective Anti-Wrinkle Efficacy. Pharmaceutics. 2023 Feb 22;15(3):731.
- [2]. Wang Q, et al. The synergistic effect of retinyl propionate and hydroxypinacolone retinoate on skin aging. Journal of cosmetic dermatology. 2023 Jul;22(7):2040-2049. [Content Brief]
Keywords
