2. GPCR/G Protein Protein Tyrosine Kinase/RTK
  3. GHSR Insulin Receptor
  4. Ibutamoren

Ibutamoren  (Synonyms: MK-677 free base; MK-0677 free base)

製品番号: HY-10199A 純度: 99.84% ee.: 99.02%
COA 取扱説明書 Technical Support

Ibutamoren (MK-677 free base; MK-0677 free base) is an orally active non-peptide growth hormone secretagogue receptor agonist. Ibutamoren activates signal cascades by mimicking endogenous ligands, triggers pulsatile release of growth hormone from the pituitary gland, and increases serum levels of IGF-1 and insulin-like growth factor-binding protein 3. Ibutamoren not only increases the frequency of growth hormone pulses in male individuals, but also promotes elevated bone formation markers in female individuals with postmenopausal osteoporosis. The combination of Ibutamoren with Alendronate sodium hydrate (HY-11101) significantly increases bone mineral density at the femoral neck. However, Ibutamoren may cause mild, reversible adverse reactions such as increased appetite, fluid retention, and elevated fasting blood glucose. Ibutamoren has been widely used in studies related to idiopathic growth hormone deficiency, sarcopenia, Alzheimer's disease, and osteoporosis.

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Ibutamoren

Ibutamoren 構造式

CAS 番号 : 159634-47-6

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 63 在庫あり
Solution
10 mM * 1 mL in DMSO USD 63 在庫あり
Solid
5 mg $54 在庫あり
10 mg $86 在庫あり
25 mg $172 在庫あり
50 mg $275 在庫あり
100 mg $440 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 5 publication(s) in Google Scholar

Other Forms of Ibutamoren:

Ibutamoren 関連抗体

Top Publications Citing Use of Products

GHSR アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
GHSR1a

  • 生物活性

  • 純度とドキュメンテーション

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製品説明

Ibutamoren (MK-677 free base; MK-0677 free base) is an orally active non-peptide growth hormone secretagogue receptor agonist. Ibutamoren activates signal cascades by mimicking endogenous ligands, triggers pulsatile release of growth hormone from the pituitary gland, and increases serum levels of IGF-1 and insulin-like growth factor-binding protein 3. Ibutamoren not only increases the frequency of growth hormone pulses in male individuals, but also promotes elevated bone formation markers in female individuals with postmenopausal osteoporosis. The combination of Ibutamoren with Alendronate sodium hydrate (HY-11101) significantly increases bone mineral density at the femoral neck. However, Ibutamoren may cause mild, reversible adverse reactions such as increased appetite, fluid retention, and elevated fasting blood glucose. Ibutamoren has been widely used in studies related to idiopathic growth hormone deficiency, sarcopenia, Alzheimer's disease, and osteoporosis[1][2][3].

IC50 & Target

GHSR1a

 

Cellular Effect
Cell Line Type Value Description References
COS-7 IC50
0.51 nM
Compound: 25
Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cells
Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cells
[PMID: 12477342]
HEK293 EC50
1.43 nM
Compound: MK-677
Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a
Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a
[PMID: 11459669]
Pituitary gland cell EC50
0.6 nM
Compound: MK-677
Concentration required for GH release from isolated pituitary cells of rat tested in vitro
Concentration required for GH release from isolated pituitary cells of rat tested in vitro
[PMID: 11459660]
Pituitary gland cell EC50
1 nM
Compound: 2
Effective concentration for their ability to release growth hormone in the rat pituitary cell assay
Effective concentration for their ability to release growth hormone in the rat pituitary cell assay
[PMID: 12729672]
Pituitary gland cell EC50
1.3 nM
Compound: 3a(MK-677)
Effective Concentration for GH secretion from rat pituitary cell was determined
Effective Concentration for GH secretion from rat pituitary cell was determined
[PMID: 8627599]
Pituitary gland cell EC50
1.3 nM
Compound: L-163191
In vitro growth hormone release was determined in rat pituitary cell assay
In vitro growth hormone release was determined in rat pituitary cell assay
[PMID: 9925440]
Pituitary gland cell EC50
1.3 nM
Compound: MK 0677
Stimulation of growth hormone secretion in rat pituitary cells
Stimulation of growth hormone secretion in rat pituitary cells
[PMID: 35344905]
Pituitary gland cell EC50
1.3 nM
Compound: MK-0677
Agonist activity at GHS-R1a in rat pituitary cells
Agonist activity at GHS-R1a in rat pituitary cells
[PMID: 23816043]
Pituitary gland cell EC50
1.3 nM
Compound: MK-677
Effective concentration for ability to release growth hormone from rat pituitary cells
Effective concentration for ability to release growth hormone from rat pituitary cells
[PMID: 11708912]
Pituitary gland cell EC50
1.3 nM
Compound: MK-677
In vitro growth hormone releasing activity was measured in rat pituitary cells
In vitro growth hormone releasing activity was measured in rat pituitary cells
[PMID: 11741481]
Pituitary gland cell EC50
1.5 nM
Compound: MK-0677
Stimulation of growth hormone in rat pituitary cell
Stimulation of growth hormone in rat pituitary cell
[PMID: 17482461]
Pituitary gland cell IC50
1.3 μM
Compound: 2
The effective concentration against rat pituitary cell GH release assay
The effective concentration against rat pituitary cell GH release assay
[PMID: 10636230]
体内実験

Ibutamoren (p.o.; daily) increases and sustains elevated serum IGF-I levels in healthy beagle dogs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
臨床実験
分子量

528.66

分子式

C27H36N4O5S
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=S(N1C2=C(C(CCN3C([C@@H](COCC4=CC=CC=C4)NC(C(C)(C)N)=O)=O)(CC3)C1)C=CC=C2)(C)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 62.5 mg/mL (118.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8916 mL 9.4579 mL 18.9157 mL
5 mM 0.3783 mL 1.8916 mL 3.7832 mL
10 mM 0.1892 mL 0.9458 mL 1.8916 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 99.84% ee.: 99.02%

COA (258 KB) HNMR (245 KB) RP-HPLC (259 KB) NP-HPLC (134 KB) LCMS (93 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8916 mL 9.4579 mL 18.9158 mL 47.2894 mL
5 mM 0.3783 mL 1.8916 mL 3.7832 mL 9.4579 mL
10 mM 0.1892 mL 0.9458 mL 1.8916 mL 4.7289 mL
15 mM 0.1261 mL 0.6305 mL 1.2611 mL 3.1526 mL
20 mM 0.0946 mL 0.4729 mL 0.9458 mL 2.3645 mL
25 mM 0.0757 mL 0.3783 mL 0.7566 mL 1.8916 mL
30 mM 0.0631 mL 0.3153 mL 0.6305 mL 1.5763 mL
40 mM 0.0473 mL 0.2364 mL 0.4729 mL 1.1822 mL
50 mM 0.0378 mL 0.1892 mL 0.3783 mL 0.9458 mL
60 mM 0.0315 mL 0.1576 mL 0.3153 mL 0.7882 mL
80 mM 0.0236 mL 0.1182 mL 0.2364 mL 0.5911 mL
100 mM 0.0189 mL 0.0946 mL 0.1892 mL 0.4729 mL
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Ibutamoren Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ibutamoren159634-47-6MK-677MK-0677MK677MK 677MK0677MK 0677GHSRInsulin ReceptorGrowth hormone secretagogue receptorGhrelin receptorfibromyalgiagrowth hormone secretagogue receptorinsulin-like growth factor Ipostmenopausal osteoporotic womenAlzheimer's diseaseyoung healthy menpituitary glandgrowth hormoneinsulin-like growth factor binding protein 3idiopathic growth hormone deficiencyInhibitorinhibitorinhibit

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製品名:
Ibutamoren
製品番号:
HY-10199A
数量:
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