2. Immunology/Inflammation
  3. Interleukin Related
  4. IL-4-inhibitor-1

IL-4-inhibitor-1 (compound 52) is an IL-4 inhibitor, with an EC50 of 1.81 µM.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS : 1332184-63-0

Tamaño Precio Stock Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
1 mg En stock
5 mg En stock
10 mg En stock
25 mg En stock
50 mg En stock
100 mg En stock
200 mg   Obtener un presupuesto  
500 mg   Obtener un presupuesto  

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Revisión del cliente

Based on 3 publication(s) in Google Scholar

IL-4-inhibitor-1 Related Antibodies

Top Publications Citing Use of Products
Histological Imaging/Staining
In Vivo Efficacy Study
WB
IF

    IL-4-inhibitor-1 purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2025 Aug;31(8):e70572.  [Abstract]

    HE staining of colon tissue treated with IL‐4 inhibitor (10 mg/kg, i.p.).

    IL-4-inhibitor-1 purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2025 Aug;31(8):e70572.  [Abstract]

    Colon length in the MOD, IL‐4 inhibitor, and EA + IL‐4 inhibitor (10 mg/kg, i.p.) groups was significantly shortened.

    IL-4-inhibitor-1 purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2025 Aug;31(8):e70572.  [Abstract]

    Protein expression levels of IL‐1β, IL‐4, IL‐10, and TGF‐β1 in colon tissue treated with IL‐4 inhibitor (10 mg/kg, i.p.).

    IL-4-inhibitor-1 purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2025 Aug;31(8):e70572.  [Abstract]

    Expression of Iba‐1 and CD206 in the hippocampal region of mice treated with IL‐4 inhibitor (10 mg/kg, i.p.).

    Ver todos los productos específicos de isoformas Interleukin Related:

    Ver todas las isoformas
    IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

    • Actividad biológica

    • Pureza y Documentación

    • Referencias

    • Revisión del cliente

    Descripciòn

    IL-4-inhibitor-1 (compound 52) is an IL-4 inhibitor, with an EC50 of 1.81 µM[1].

    IC50 & Target

    EC50: 1.81 µM (IL-4)[1].
    In Vitro

    IL-4-inhibitor-1 (compound 52) displays low micromolar affinity and exhibits functional disruption of type II IL-4 binding in a cellular context[1].
    IL-4-inhibitor-1 (compound 52) exhibits dose-dependent reduction in pSTAT-6 levels with an EC50 value of 3.1 µM, but did not affect the levels of STAT-6[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    IL-4-inhibitor-1 Related Antibodies
    Peso molecular

    321.31

    Fòrmula

    C18H12FN3O2
    No. CAS
    Appearance

    Solid

    Color

    Light yellow to yellow

    SMILES

    N#CC1=C(C2=CC=C(O)C(O)=C2)C=C(C3=CC=C(F)C=C3)N=C1N
    Envío

    Room temperature in continental US; may vary elsewhere.
    Almacenamiento
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvente y solubilidad
    In Vitro: 

    DMSO : 100 mg/mL (311.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.1123 mL 15.5613 mL 31.1226 mL
    5 mM 0.6225 mL 3.1123 mL 6.2245 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Calculadora de molaridad

    • Calculadora de dilución

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: 2.5 mg/mL (7.78 mM); Suspended solution; Need ultrasonic

      This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Pureza y Documentación
    Referencias

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.1123 mL 15.5613 mL 31.1226 mL 77.8065 mL
    5 mM 0.6225 mL 3.1123 mL 6.2245 mL 15.5613 mL
    10 mM 0.3112 mL 1.5561 mL 3.1123 mL 7.7806 mL
    15 mM 0.2075 mL 1.0374 mL 2.0748 mL 5.1871 mL
    20 mM 0.1556 mL 0.7781 mL 1.5561 mL 3.8903 mL
    25 mM 0.1245 mL 0.6225 mL 1.2449 mL 3.1123 mL
    30 mM 0.1037 mL 0.5187 mL 1.0374 mL 2.5935 mL
    40 mM 0.0778 mL 0.3890 mL 0.7781 mL 1.9452 mL
    50 mM 0.0622 mL 0.3112 mL 0.6225 mL 1.5561 mL
    60 mM 0.0519 mL 0.2594 mL 0.5187 mL 1.2968 mL
    80 mM 0.0389 mL 0.1945 mL 0.3890 mL 0.9726 mL
    100 mM 0.0311 mL 0.1556 mL 0.3112 mL 0.7781 mL
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    IL-4-inhibitor-1 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    IL-4-inhibitor-11332184-63-0Interleukin RelatedILAsthmacancerIL-4Inhibitorinhibitorinhibit

    Productos vistos recientemente:

    Consulta en línea

    Your information is safe with us. * Required Fields.

    Nombre del producto

    		  

    Requested Quantity *

    Nombre del solicitante *

    		 

    Saludo

    Direcciòn del E-mail *

    		 

    Número de teléfono *

    Department

    		 

    Nombre de la Organizaciòn *

    City

    Provincia

    Country or Region *

    		      

    Observaciones

    Consulta para venta a granel

    Inquiry Information

    Nombre del producto:
    IL-4-inhibitor-1
    Cat. No.:
    HY-139092
    Cantidad:
    MCE Japan Authorized Agent:

    Revisión del cliente

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    Nombre del producto

    		  

    Lot #

    Nombre del solicitante *

    		 

    Direcciòn del E-mail *

    Número de teléfono

    		 

    Department *

    Nombre de la Organizaciòn *

    		 

    Country or Region *

    Observaciones

    SAFETY DATA SHEET (SDS)

    English - EN (251 KB) Français - FR (251 KB) Deutsch - DE (251 KB) Norwegian - NO (251 KB) Español - ES (251 KB) Swedish - SV (251 KB) Italian - IT (251 KB) Korean - KR (251 KB) Portuguese - PT (251 KB)

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.