2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. IMP-1088

IMP-1088 is a potent human N-myristoyltransferases NMT1 and NMT2 dual inhibitor with IC50s of <1 nM for HsNMT1 and HsNMT2. IMP-1088 has a Kd of <210 pM for HsNMT1. IMP-1088 efficiently blocks rhinovirus replication by blocking rhinovirus virus-encoded protein (VP0) N-myristoylation. IMP-1088 protects host cells from the cytotoxic effects of viral infection.

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CAS 番号 : 2059148-82-0

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 396 在庫あり
Solution
10 mM * 1 mL in DMSO USD 396 在庫あり
Solid
1 mg $180 在庫あり
5 mg $360 在庫あり
10 mg $595 在庫あり
25 mg $1200 在庫あり
50 mg $1990 在庫あり
100 mg $3100 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 8 publication(s) in Google Scholar

IMP-1088 関連抗体

Top Publications Citing Use of Products

    IMP-1088 purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2026 Feb 18:37:102945.

    Viability of Calu-1 cells pretreated with DMSO or 1 μM IMP-1088, then exposed to erastin or ML162 ± Fer-1.

    IMP-1088 purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2026 Feb 18:37:102945.

    Volcano plot for Calu-1 cells shows YnMyr incorporation versus significance in the presence of IMP-1088. Confidence categories: high (blue), medium (green; circle, rhombus, triangle), low (yellow), potential (purple), non-substrates (gray).

    IMP-1088 purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2026 Feb 18:37:102945.

    Western blot analysis of GLIPR2 myristoylation in GLIPR2-knockout Calu-1 cells reconstituted as indicated, and treated with or without 1 μM IMP-1088.

    IMP-1088 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2023 Mar 3.

    Representative immunofluorescence staining images of A549-AT lung cells treated with indicated concentrations of IMP-1088 (62.5 nM, 1 μM) or DMSO vehicle control, 1.5 hours before-infection (hbi) or post-infection (hpi) and infected with SARS-CoV-2 wuh for 24 h. Viral markers N (magenta) and dsRNA (yellow), actin (green) and nuclei (DAPI, blue).

    IMP-1088 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2023 Mar 3.

    Representative immunofluorescence images and (E) quantification of SARS-CoV-2 wuh infection (normalized to number of nuclei) in A549-AT cells treated with indicated concentrations of IMP-1088 or DMSO vehicle control 1.5 hbi, infected with for 48 h and stained against N (magenta), actin (green), and nuclei (blue). The boxed areas i (multi-nucleated syncytium of cells), ii and iii (infected single cells) are shown magnified at the bottom of each image.

    IMP-1088 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2023 Mar 3.

    Representative immunofluorescence images of human primary nasal epithelial cells grown as a pseudostratified columnar epithelium and treated with IMP-1088 (1 µM) or Nafamostat and Apilimod (20 µM and 0.25 µM, respectively) or DMSO vehicle control and infected with SARS-CoV-2 wuh for 72 h and stained against viral markers N (yellow), actin (magenta) and nuclei (cyan).

    IMP-1088 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2023 Mar 3.

    Quantification of relative infection (number of GFP positive cells normalized to the number of nuclei) of RSV-GFP 24 hpi and 48 hpi (P), SFV-GFP at 12 hpi and 24 hpi (Q), and VSV-GFP at 12 hpi and 24 hpi (R), respectively, in DMSO and 0.01-1 µM IMP-1088 treated A549 cells (at 2 hbi or 1 hbi).

    DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    IMP-1088 is a potent human N-myristoyltransferases NMT1 and NMT2 dual inhibitor with IC50s of <1 nM for HsNMT1 and HsNMT2. IMP-1088 has a Kd of <210 pM for HsNMT1. IMP-1088 efficiently blocks rhinovirus replication by blocking rhinovirus virus-encoded protein (VP0) N-myristoylation. IMP-1088 protects host cells from the cytotoxic effects of viral infection[1].

    IC50 & Target

    IC50: <1 nM (HsNMT1) and <1 nM (HsNMT2)[1]
    Kd: <210 pM (HsNMT1)[1]
    体外実験

    IMP-1088 (1-1000 nM) prevents virus-induced cytopathic effect (CPE) in a dose-dependent manner with an IC50 of 17 nM. IMP-1088 (125 nM) complete suppresses of new infectious virus with an IC50 of 5.8 nM. IMP-1088 (1-1000 nM) blocks production of infectious virus and inhibits single cycle replication in primary human bronchial epithelial cells (hBEC) infected with rhinovirus RV-A1 (MOI 5) for 7 h. IMP-1088 significantly inhibits production of infectious virus even when added up to 3 hours post-infection[1].
    IMP-1088 (50 nM) significantly less enriches multiple N-myristoylated proteins in enriched samples[1].
    IMP-1088 (500 nM) inhibits production of infectious rhinovirus particles by blocking virus assembly in HeLa cells infected with rhinovirus RV-A16 (MOI 20) for 6 h[1].
    IMP-1088 (0.24 nM-1 μM; for 24 hours +24 hours washout) has no long-term effect on cell viability and NMT activity fully recovers by 24 h[1].
    IMP-1088 potently blocks a key step in viral capsid assembly by inhibition of co-translational myristoylation of a specific virus-encoded protein (VP0). IMP-1088 blocks neither production of viral RNA, nor translation of rhinovirus polyprotein[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    IMP-1088 関連抗体
    分子量

    453.53

    分子式

    C25H29F2N5O
    CAS 番号
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    CN1N=C(CN(C)C)C2=C1C=CC(C3=CC=C(F)C(F)=C3OCCC4=C(C)N(C)N=C4C)=C2
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    -20°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    溶剤 & 溶解度
    体外: 

    DMSO : 100 mg/mL (220.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.2049 mL 11.0246 mL 22.0493 mL
    5 mM 0.4410 mL 2.2049 mL 4.4099 mL
    10 mM 0.2205 mL 1.1025 mL 2.2049 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

    ×
    体積 （終了）

    V2

    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (5.51 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (5.51 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.16%

    COA (254 KB) HNMR (262 KB) LCMS (96 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.2049 mL 11.0246 mL 22.0493 mL 55.1231 mL
    5 mM 0.4410 mL 2.2049 mL 4.4099 mL 11.0246 mL
    10 mM 0.2205 mL 1.1025 mL 2.2049 mL 5.5123 mL
    15 mM 0.1470 mL 0.7350 mL 1.4700 mL 3.6749 mL
    20 mM 0.1102 mL 0.5512 mL 1.1025 mL 2.7562 mL
    25 mM 0.0882 mL 0.4410 mL 0.8820 mL 2.2049 mL
    30 mM 0.0735 mL 0.3675 mL 0.7350 mL 1.8374 mL
    40 mM 0.0551 mL 0.2756 mL 0.5512 mL 1.3781 mL
    50 mM 0.0441 mL 0.2205 mL 0.4410 mL 1.1025 mL
    60 mM 0.0367 mL 0.1837 mL 0.3675 mL 0.9187 mL
    80 mM 0.0276 mL 0.1378 mL 0.2756 mL 0.6890 mL
    100 mM 0.0220 mL 0.1102 mL 0.2205 mL 0.5512 mL
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    IMP-1088 Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    IMP-10882059148-82-0IMP1088IMP 1088DNA/RNA SynthesishumanN-myristoyltransferasesNMT1NMT2HsNMT1HsNMT2rhinovirusreplicationvirus-encodedproteinVP0hBECRV-A16HeLabronchialepithelialInhibitorinhibitorinhibit

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    製品名:
    IMP-1088
    製品番号:
    HY-112258
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