Ionizable lipid-1

Name: Ionizable lipid-1
Brand: MedChemExpress
SKU: HY-156630
Rating: 4.5 (1 reviews)

製品番号: HY-156630 純度: 98.0%: Data Sheet SDS COA 取扱説明書
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Ionizable lipid-1 (compound II-10) is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure.

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Ionizable lipid-1 構造式

CAS 番号 : 2055939-68-7

容量	価格（税別）	在庫状況	数量
5 mg	$290	在庫あり	Estimated Time of Arrival: December 31
10 mg	$460	在庫あり	Estimated Time of Arrival: December 31
25 mg	$930	在庫あり	Estimated Time of Arrival: December 31
50 mg	$1500	在庫あり	Estimated Time of Arrival: December 31
100 mg	$2400	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Other Forms of Ionizable lipid-1:

Ionizable lipid-1 hydrochloride お問い合わせ

顧客検証

•Mol Ther. 2024 Jul 2:S1525-0016(24)00403-9. [Abstract]

おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Ionizable lipid-1 (compound II-10) is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure^[1].

体外実験

Ionizable lipid-1 can be protonated and positively charged at acidic pH. Ionizable lipid-1 electrostatically binds to negatively charged RNA molecules, thereby encapsulating RNA into nanoparticles. Ionizable lipid-1 will be protonated again once entering cells, interacts with the negatively charged endosome membrane. The interaction leads to the disruption of the endosome membrane, thereby releasing the RNA payload into the cytoplasm^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

919.54

分子式

C₅₈H₁₁₄N₂O₅

CAS 番号

2055939-68-7

Appearance

Liquid (Density: 0.914±0.06 g/cm³)

Color

Colorless to light yellow

SMILES

O=C(CCCCCCCCC(CCCCCCCCC(OC(CCCCCC)CCCCCC)=O)N(CCCN(C)C)C(CCCCCCC)=O)OC(CCCCCC)CCCCCC

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

Methanol : 50 mg/mL (54.38 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0875 mL	5.4375 mL	10.8750 mL
5 mM	0.2175 mL	1.0875 mL	2.1750 mL
10 mM	0.1088 mL	0.5438 mL	1.0875 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 98.0%

Select Batch:

データシート (267 KB) SDS (254 KB)

COA (240 KB) HNMR (335 KB) MS (70 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Thomas D Madden, et al. Lamellar lipid nanoparticles. Patent WO2019089828A1.

[2]. Ramaswamy S, et al., Systemic delivery of factor IX messenger RNA for protein replacement therapy. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E1941-E1950. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Methanol	1 mM	1.0875 mL	5.4375 mL	10.8750 mL	27.1875 mL
	5 mM	0.2175 mL	1.0875 mL	2.1750 mL	5.4375 mL
	10 mM	0.1088 mL	0.5438 mL	1.0875 mL	2.7188 mL
	15 mM	0.0725 mL	0.3625 mL	0.7250 mL	1.8125 mL
	20 mM	0.0544 mL	0.2719 mL	0.5438 mL	1.3594 mL
	25 mM	0.0435 mL	0.2175 mL	0.4350 mL	1.0875 mL
	30 mM	0.0363 mL	0.1813 mL	0.3625 mL	0.9063 mL
	40 mM	0.0272 mL	0.1359 mL	0.2719 mL	0.6797 mL
	50 mM	0.0218 mL	0.1088 mL	0.2175 mL	0.5438 mL