Ionizable lipid-1

Name: Ionizable lipid-1
Brand: MedChemExpress
SKU: HY-156630
Rating: 4.5 (1 reviews)

Art. -Nr.: HY-156630 Reinheit: 98.0%: Data Sheet
COA

SDS
Handling Instructions
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Ionizable lipid-1 (compound II-10) is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure.

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Ionizable lipid-1 Chemische Struktur

CAS. Nr. : 2055939-68-7

Größe	Verfügbarkeit	Menge
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
25 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Auf Lager	Estimated Time of Arrival: December 31
100 mg	Auf Lager	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of Ionizable lipid-1:

Ionizable lipid-1 hydrochloride Angebot einholen

1 Publications Citing Use of MCE Ionizable lipid-1

•Mol Ther. 2024 Jul 2:S1525-0016(24)00403-9. [Abstract]

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biologische Aktivität
Reinheit & Dokumentation
Verweise
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Beschreibung

Ionizable lipid-1 (compound II-10) is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure^[1].

In Vitro

Ionizable lipid-1 can be protonated and positively charged at acidic pH. Ionizable lipid-1 electrostatically binds to negatively charged RNA molecules, thereby encapsulating RNA into nanoparticles. Ionizable lipid-1 will be protonated again once entering cells, interacts with the negatively charged endosome membrane. The interaction leads to the disruption of the endosome membrane, thereby releasing the RNA payload into the cytoplasm^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molekulargewicht

919.54

Formel

C₅₈H₁₁₄N₂O₅

CAS. Nr.

2055939-68-7

Appearance

Liquid (Density: 0.914±0.06 g/cm³)

Color

Colorless to light yellow

SMILES

O=C(CCCCCCCCC(CCCCCCCCC(OC(CCCCCC)CCCCCC)=O)N(CCCN(C)C)C(CCCCCCC)=O)OC(CCCCCC)CCCCCC

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

Methanol : 50 mg/mL (54.38 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0875 mL	5.4375 mL	10.8750 mL
5 mM	0.2175 mL	1.0875 mL	2.1750 mL
10 mM	0.1088 mL	0.5438 mL	1.0875 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 98.0%

Select Batch:

Data Sheet (267 KB) SDS (254 KB)

COA (240 KB) HNMR (335 KB) MS (70 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Thomas D Madden, et al. Lamellar lipid nanoparticles. Patent WO2019089828A1.

[2]. Ramaswamy S, et al., Systemic delivery of factor IX messenger RNA for protein replacement therapy. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E1941-E1950. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Methanol	1 mM	1.0875 mL	5.4375 mL	10.8750 mL	27.1875 mL
	5 mM	0.2175 mL	1.0875 mL	2.1750 mL	5.4375 mL
	10 mM	0.1088 mL	0.5438 mL	1.0875 mL	2.7188 mL
	15 mM	0.0725 mL	0.3625 mL	0.7250 mL	1.8125 mL
	20 mM	0.0544 mL	0.2719 mL	0.5438 mL	1.3594 mL
	25 mM	0.0435 mL	0.2175 mL	0.4350 mL	1.0875 mL
	30 mM	0.0363 mL	0.1813 mL	0.3625 mL	0.9063 mL
	40 mM	0.0272 mL	0.1359 mL	0.2719 mL	0.6797 mL
	50 mM	0.0218 mL	0.1088 mL	0.2175 mL	0.5438 mL