LM-299 

LM-299 is a PD-1/VEGF bispecific antibody. LM-299 achieves its dual binding activity through the effective binding of the anti-VEGF-A antibody at the fab end to human VEGF-A, coupled with the blockade of the PD-1/PD-L1 pathway by the anti-PD-1 antibody at the-Fc end. LM-299 can be used for the study of non-small cell lung cancer (NSCLC).

Human IgG1 kappa

Human IgG1 kappa, Isotype Control

Human

29126  [NCBI] & 7422  [NCBI]

Q9NZQ7 & P15692

PD-1 & VEGF

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

175.49 kDa

Liquid

Colorless to light yellow

[LM-299]

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• 
  Tetravalent IgG-VHH

• 
  Immobilized Human PD-1 Protein, His Tag can bind LM-299. The EC₅₀ for this effect is 164.3 ng/mL.
• 
  Immobilized Human VEGF165 Protein,hFc Tag can bind LM-299. The EC₅₀ for this effect is 77.9 ng/mL.