2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis Eukaryotic Initiation Factor (eIF)
  4. m7GpppAmpG ammonium solution (100 mM)

m7GpppAmpG ammonium solution (100 mM)  (Synonyms: m7G(5')ppp(5')(2'OMeA)pG ammonium)

製品番号: HY-145974A 純度: 99.96%
COA 取扱説明書 Technical Support

m7GpppAmpG ammonium (m7G(5')ppp(5')(2'OMeA)pG ammonium) is a trinucleotide 5′ end cap analog. m7GpppAmpG ammonium binds to eIF4E with a KD value of 45.6 nM. m7GpppAmpG ammonium caps RNA with a capping efficiency of 90%. m7GpppAmpG ammonium enhances mRNA stability and translation efficiency. m7GpppAmpG ammonium is used in mRNA therapeutic research.

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m7GpppAmpG ammonium solution (100 mM)

m7GpppAmpG ammonium solution (100 mM) 構造式

CAS 番号 : 3080642-79-8

容量 価格（税別） 在庫状況 数量
Solvent
20 μL USD 95 在庫あり
Solvent
50 μL USD 190 在庫あり
Solvent
100 μL USD 300 在庫あり
Solvent
200 μL USD 480 在庫あり

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m7GpppAmpG ammonium solution (100 mM) 関連抗体

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製品説明

m7GpppAmpG ammonium (m7G(5')ppp(5')(2'OMeA)pG ammonium) is a trinucleotide 5′ end cap analog. m7GpppAmpG ammonium binds to eIF4E with a KD value of 45.6 nM. m7GpppAmpG ammonium caps RNA with a capping efficiency of 90%. m7GpppAmpG ammonium enhances mRNA stability and translation efficiency. m7GpppAmpG ammonium is used in mRNA therapeutic research[1][2][3].

IC50 & Target[1]

eIF4E

45.6 nM (Kd)

体外実験

m7GpppAmpG ammonium enables efficient capping of RNA with 90% efficiency[1].
m7GpppAmpG ammonium binds eIF4E with a KD value of 45.6 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

m7GpppAmpG ammonium solution (100 mM) 関連抗体
体内実験

m7GpppAmpG (10 μg mRNA per mouse; intramuscular injection) ammonium demonstrates lower translational efficiency and IgG antibody levels compared to novel cap analogs YK-CAP-02~04 in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子式

C32H43N15O24P4.xNH3
CAS 番号
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=P(O)(OC[C@@H]1[C@@H](OP(O)(OC[C@H]2O[C@@H](N3C(NC(N)=NC4=O)=C4N=C3)[C@H](O)[C@@H]2O)=O)[C@@H](OC)[C@H](N5C=NC6=C(N)N=CN=C65)O1)OP(OP(OC[C@H]7O[C@@H](N8C(NC(N)=N9)=C([N+](C)=C8)C9=O)[C@H](O)[C@@H]7O)([O])=O)(O)=O.[xNH3]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Solution, -20°C, 2 years
溶剤 & 溶解度
体外: 

H2O : ≥ 100 mg/mL

*"≥" means soluble, but saturation unknown.

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純度とドキュメンテーション

純度: 99.96%

COA (261 KB) HNMR (335 KB) RP-HPLC (238 KB)

取扱説明書 (2659 KB)
参考文献
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m7GpppAmpG ammonium solution (100 mM) Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

m7GpppAmpG ammonium solution (100 mM)3080642-79-8m7G(5')ppp(5')(2'OMeA)pGDNA/RNA SynthesisEukaryotic Initiation Factor (eIF)capRNAmRNAInhibitorinhibitorinhibit

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製品名:
m7GpppAmpG ammonium solution (100 mM)
製品番号:
HY-145974A
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