2. GPCR/G Protein
  3. Leukotriene Receptor
  4. Montelukast dicyclohexylamine

Montelukast dicyclohexylamine  (Synonyms: MK0476 dicyclohexylamine)

Cat. No.: HY-13315B
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Montelukast (MK0476) dicyclohexylamine is a potent, selective and orally active antagonist of cysteinyl leukotriene receptor 1 (CysLT1). Montelukast dicyclohexylamine can be used for the reseach of asthma and liver injury. Montelukast dicyclohexylamine also has an antioxidant effect in intestinal ischemia-reperfusion injury, and could reduce cardiac damage. Montelukast dicyclohexylamine decreases eosinophil infiltration into the asthmatic airways. Montelukast dicyclohexylamine can also be used for COVID-19 research.

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CAS No. : 577953-88-9

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Montelukast dicyclohexylamine Related Antibodies

Top Publications Citing Use of Products

    Montelukast dicyclohexylamine purchased from MedChemExpress. Usage Cited in: Environ Pollut. 2026 May 1:396:127849.

    Effect of Montelukast (Mon) (500 μM) on the metabolic inhibition rate of tetraconazole enantiomers in the in vitro incubation mixtures with HLMs.

    Montelukast dicyclohexylamine purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Apr 3;16(1):3177.  [Abstract]

    Schematic diagram of subcutaneous tumor treatment on C57BL/6 mice and representative images of Montelukast (5 mg/kg; i.p.; 7-26 d) on day 26.

    Montelukast dicyclohexylamine purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Apr 3;16(1):3177.  [Abstract]

    Tumor growth of LTP-C9 with overexpression of PDHA1 WT was observed in C57BL/6 mice treated with Montelukast (5 mg/kg; i.p.; 7-26 d).

    Montelukast dicyclohexylamine purchased from MedChemExpress. Usage Cited in: SSRN. 2024 Oct 29.

    Montelukast (M) (2.5-5.0 mg/kg; i.p.; once daily for 19 weeks) reduced urine protein levels and concentrations of autoantibodies, including ANA and anti-dsDNA of MRL/Lpr mice.

    Montelukast dicyclohexylamine purchased from MedChemExpress. Usage Cited in: SSRN. 2024 Oct 29.

    Montelukast (M) (2.5-5.0 mg/kg; i.p.; once daily for 19 weeks) decreased the percentages of ASCs, plasma cells, and plasmablasts in the spleen of MRL/Lpr mice.

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    LTB4 LTC4/CysLT2 LTD4/CysLT1 LTE4

    • Biological Activity

    • 순도&문서

    • References

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    제품 설명

    Montelukast (MK0476) dicyclohexylamine is a potent, selective and orally active antagonist of cysteinyl leukotriene receptor 1 (CysLT1). Montelukast dicyclohexylamine can be used for the reseach of asthma and liver injury. Montelukast dicyclohexylamine also has an antioxidant effect in intestinal ischemia-reperfusion injury, and could reduce cardiac damage. Montelukast dicyclohexylamine decreases eosinophil infiltration into the asthmatic airways. Montelukast dicyclohexylamine can also be used for COVID-19 research[1][2][3][4].

    IC50 & Target

    CysLT1

     

    In Vitro

    Montelukast (5 μM; 1 h) inhibits APAP (Acetaminophen) (HY-66005)-induced cell damage[1].
    Montelukast (0.01-10 μM; 30 min) diminishes the 5-oxo-ETE–induced cell migration and modulates the activation of the plasmin-plasminogen system[3].
    Montelukast (10 μM; 18 h) modulates the activation of MMP-9[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Montelukast dicyclohexylamine Related Antibodies

    Cell Migration Assay [3]

    Cell Line: Eosinophils
    Concentration: 0.01-10 μM
    Incubation Time: 30 min
    Result: Diminished the 5-oxo-ETE–induced cell migration.

    Western Blot Analysis[3]

    Cell Line: Eosinophils
    Concentration: 10 μM
    Incubation Time: 18 h
    Result: Reduced the 5-oxo-ETE–boosted MMP-9 secretion.
    In Vivo

    Montelukast (3 mg/kg; oral gavage) protects against APAP-induced hepatotoxicity in mice[1].
    Montelukast (1 mg/kg; miniosmotic pump administration) reduces the airway remodeling changes observed in OVA-treated mice and blocks the actions of cysteinyl leukotrienes (LT) C4, D4, and E4 mediated by the CysLT1 receptor[2].
    Montelukast (1 mg/kg; miniosmotic pump administration) reduces the elevated levels of IL-4 and IL-13 found in the BAL fluid of OVA-treated mice[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: C57BL/6J mice (8-week-old; 22-25 g) are induced acute hepatic injury[1]
    Dosage: 3 mg/kg
    Administration: Oral gavage 1 h after saline or APAP administration
    Result: Decreased serum levels of alanine transaminase (ALT) and aspartate aminotransferase (AST), and alleviated liver damage.
    분자량

    767.50

    화학식

    C47H59ClN2O3S
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    CC(C)(O)C(C=CC=C1)=C1CC[C@H](C2=CC(/C=C/C3=NC4=C(C=CC(Cl)=C4)C=C3)=CC=C2)SCC5(CC5)CC(O)=O.C6(CCCCC6)NC7CCCCC7
    선적

    Room temperature in continental US; may vary elsewhere.
    보관

    Please store the product under the recommended conditions in the Certificate of Analysis.
    순도&문서
    References
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    Montelukast dicyclohexylamine Related Classifications

    • 몰농도 계산기

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    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Montelukast577953-88-9MK0476MK 0476MK-0476Leukotriene ReceptorcysteinylleukotrieneCysltr1asthmaliverinjuryantioxidantintestinalischemia–reperfusionicardiacdamageCOVID-19Inhibitorinhibitorinhibit

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    Montelukast dicyclohexylamine
    Cat. No.:
    HY-13315B
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