2. Apoptosis
  3. Bcl-2 Family
  4. Navitoclax dihydrochloride

Navitoclax dihydrochloride  (Synonyms: ABT-263 dihydrochloride)

製品番号: HY-10087A1
取扱説明書 Technical Support

Navitoclax (ABT-263) dihydrochloride is an orally active Bcl-2 inhibitor that binds to various Bcl-2 family proteins, including Bcl-xL, Bcl-2, and Bcl-w, with a Ki value of less than 1 nM. Navitoclax dihydrochloride can be used in cancer research.

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CAS 番号 : 1093851-28-5

容量 価格（税別） 在庫状況 数量
5 mg $65 お問い合わせ 5 - 7 weeks 4 - 6 weeks 6 - 8 weeks 4 - 6 weeks
10 mg $100 お問い合わせ 5 - 7 weeks 4 - 6 weeks 6 - 8 weeks 4 - 6 weeks
25 mg $180 お問い合わせ 5 - 7 weeks 4 - 6 weeks 6 - 8 weeks 4 - 6 weeks
50 mg $250 お問い合わせ 5 - 7 weeks 4 - 6 weeks 6 - 8 weeks 4 - 6 weeks
100 mg $350 お問い合わせ 5 - 7 weeks 4 - 6 weeks 6 - 8 weeks 4 - 6 weeks
200 mg   お問い合わせ  
500 mg   お問い合わせ  
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Based on 150 publication(s) in Google Scholar

Other Forms of Navitoclax dihydrochloride:

Navitoclax dihydrochloride 関連抗体

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顧客検証

Cell Proliferation/Viability Assay
WB
RT-PCR

    Navitoclax dihydrochloride purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2024 Sep 6;43(1):253.  [Abstract]

    The co-treatment with ABT-263 (Navitoclax) (0.2 μM) and KRIBB-11 inhibits the cell viability in iCCA hCAFs. Effect of ABT-263, KRIBB-11, and their co-administration on the viability of iCCA hCAFs, grown for 72 h in culture medium supplemented with 10% FBS. Note the higher anti-growth effects of the two combined drugs than single treatments.

    Navitoclax dihydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Nov 10;13(1):6803.  [Abstract]

    Navitoclax (0.5-1.5 μM;10 d) combined with decitabine significantly reduces the transcriptional activity of KIAA1522-a6 in siPTBP1-transfected A2780 cells.

    Navitoclax dihydrochloride purchased from MedChemExpress. Usage Cited in: Cell Discov. 2022 Oct 6;8(1):102.  [Abstract]

    Cell viability of the captured clones in response to ABT263 (Navitoclax) (2 days). Results are representative of two independent experiments with three technical replicates per experiment, and error bars represent SEM.

    Navitoclax dihydrochloride purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Sep 24;9(10):986.  [Abstract]

    Cells are treated with 25 nM siRNA for 48 hours followed by 1 μM ABT-263 for 36 hours.

    Navitoclax dihydrochloride purchased from MedChemExpress. Usage Cited in: ACS Med Chem Lett. 2015 Jun 22;6(8):948-52.  [Abstract]

    Combination treatment. (a) Comparison of AZD-8055 and ABT-263 treatment in all cell lines. Red indicates sensitivity, while blue indicates resistance. (b) Depiction of synergism where the values shown are excess over Bliss Independence, a prediction of inhibition without synergism. Increased synergism is evident by an increased number, shown in red, while negative numbers in blue represent an antagonistic effect.

    Bcl-2 Family アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3 Bad

    • 生物活性

    • 純度とドキュメンテーション

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    製品説明

    Navitoclax (ABT-263) dihydrochloride is an orally active Bcl-2 inhibitor that binds to various Bcl-2 family proteins, including Bcl-xL, Bcl-2, and Bcl-w, with a Ki value of less than 1 nM. Navitoclax dihydrochloride can be used in cancer research[1].

    分子量

    1047.53

    分子式

    C47H57Cl3F3N5O6S3
    CAS 番号
    SMILES

    O=C(C1=CC=C(N2CCN(CC2)CC3=C(CCC(C)(C3)C)C4=CC=C(Cl)C=C4)C=C1)NS(=O)(C5=CC=C(C(S(=O)(C(F)(F)F)=O)=C5)N[C@H](CCN6CCOCC6)CSC7=CC=CC=C7)=O.Cl.Cl
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    Please store the product under the recommended conditions in the Certificate of Analysis.
    純度とドキュメンテーション
    参考文献
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    Navitoclax dihydrochloride Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Navitoclax1093851-28-5ABT-263ABT263ABT 263Bcl-2 FamilyInhibitorinhibitorinhibit

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    製品番号:
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