2. Anticuerpos inhibidores
  3. Biosimilar Antibodies
  4. Monoclonal Antibodies
  5. Ociperlimab

Ociperlimab  (Synonyms: BGB-A1217)

Cat. No.: HY-P99763 Pureza: 98.14%
COA
SDS
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Ociperlimab is a humanized IgG1 anti-TIGIT antibody. Ociperlimab binds to the extracellular domain of human TIGIT with high affinity (KD = 0.135 nM). Ociperlimab blocks the interaction between TIGIT and its ligands PVR or PVR-L2. Ociperlimab can be used in research of cancer.

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No. CAS : 2342597-93-5

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Ociperlimab Related Antibodies

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Descripciòn

Ociperlimab is a humanized IgG1 anti-TIGIT antibody. Ociperlimab binds to the extracellular domain of human TIGIT with high affinity (KD = 0.135 nM). Ociperlimab blocks the interaction between TIGIT and its ligands PVR or PVR-L2. Ociperlimab can be used in research of cancer[1][2].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

TIGIT
In Vitro

Ociperlimab (BGB-A1217; 0-10 μg/mL) enhances IFN-γ secretion by cytomegalovirus-specific T cells[1].
Ociperlimab (1-1000 ng/mL) activates NK and monocytes in an Fc-dependent manner[1].
Ociperlimab removes TIGIT from T cell surface through Fc-dependent endocytosis in vitro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ociperlimab Related Antibodies
In Vivo

Ociperlimab (BGB-A1217; 3 and 10 mg/kg; i.p.; CT26 WT tumor-bearing humanized TIGIT knock-in mice and MC38 tumor-bearing humanized TIGIT knock-in mice) elicits anti-tumor efficacy in an Fc-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CT26 WT tumor-bearing humanized TIGIT knock-in mice and MC38 tumor-bearing humanized TIGIT knock-in mice[1]
Dosage: 3 and 10 mg/kg
Administration: Intraperitoneal injection
Result: Inhibited tumor growth compared to the single agent treatment groups.
Ensayo clínico
Gene ID

201633  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Peso molecular

145.12 kDa

No. CAS
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Ociperlimab]
Envío

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized TIGIT Protein, Human can bind Ociperlimab. The EC50 for this effect is 20.39 ng/mL.
Pureza y Documentación

Purity: 98.14%

SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (603 KB)
Referencias
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Ociperlimab Related Classifications

  • Calculadora de molaridad

  • Calculadora de dilución

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ociperlimab2342597-93-5BGB-A1217OthersPVRPVR-L2CMV-specific T cellscancerFcInhibitorinhibitorinhibit

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Nombre del producto:
Ociperlimab
Cat. No.:
HY-P99763
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