TIGIT - T cell immunoreceptor with Ig and ITIM domains Gene

Also Known as VSIG9; VSTM3; WUCAM

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 201633

About TIGIT

Cytogenetic location: 3q13.31 Genomic coordinates (GRCh38): 3:114,294,028-114,310,288 (from NCBI)

This gene has 7 transcripts (splice variants), 618 orthologues and 14 paralogues. Biased expression in lymph node (RPKM 15.1), spleen (RPKM 5.9) and 7 other tissues.

Summary

This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.[provided by RefSeq, Sep 2009]

TIGIT Products (1)

mRNA	Protein	Name
NM_173799.4	NP_776160.2	T-cell immunoreceptor with Ig and ITIM domains precursor

TIGIT Protein Structure

V-set

0
100
200
244 a.a.

Protein Preferred Names	Protein Names
T-cell immunoreceptor with Ig and ITIM domains	V-set and immunoglobulin domain containing 9

TIGIT Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TIGIT	Q495A1	PLLP	Homo sapiens	Q9Y342	Validated Y2H	32296183
Intra	TIGIT	Q495A1	PVR	Homo sapiens	P15151	SPR	28515320
Intra	TIGIT	Q495A1	CD226	Homo sapiens	Q15762	FRET	25465800
Intra	TIGIT	Q495A1	PVR	Homo sapiens	P15151-1	SPR	27978489
Intra	TIGIT	Q495A1	NECTIN2	Homo sapiens	Q92692	SPR	28515320
Intra	TIGIT	Q495A1	NECTIN2	Homo sapiens	Q92692	Protein Array	21982860
Intra	TIGIT	Q495A1	NECTIN2	Homo sapiens	Q92692	SPR	27978489
Intra	TIGIT	Q495A1	TIGIT	Homo sapiens	Q495A1	X-Ray Diffraction	27978489
Intra	TIGIT	Q495A1	TIGIT	Homo sapiens	Q495A1	GMS	27978489
Intra	TIGIT	Q495A1	NECTIN2	Homo sapiens	Q92692	GMS	28515320
Intra	TIGIT	Q495A1	NECTIN2	Homo sapiens	Q92692	X-Ray Diffraction	28515320

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TIGIT Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7414	TIGIT Protein, Human (HEK293, Fc)	Q495A1-1 (M22-P141)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70624	TIGIT Protein, Human (HEK293, His)	Q495A1-1 (M22-P141)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P71363	TIGIT Protein, Human (HEK293, mFc)	Q495A1-1 (M22-P141)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72418	TIGIT Protein, Human (HEK293, His-Avi)	Q495A1-1 (M22-P141)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78216	TIGIT Protein, Human (Biotinylated, HEK293, His-Avi)	Q495A1-1 (M22-P141)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78799	TIGIT Protein, Human (Biotinylated, HEK293, mFc-Avi)	Q495A1-1 (M22-P141)	≥ 90%, as determined by reducing SDS-PAGE.

TIGIT Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811359	TIGIT Antibody	WB	Human, Mouse
HY-P81752	TIGIT Antibody (YA1497)	FC, ELISA	Human

Related Diseases

Diseases	Alias
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Chromophobe Renal Cell Carcinoma	Chromophobe Adenocarcinoma Chromophobe Carcinoma Of Kidney Kidney Chromophobe Renal Cell Carcinoma, Chromophobe Cell Crcc Chrcc Chromophobe Renal Cell Adenocarcinoma Chromophobe Renal Carcinoma Chromophobe Carcinoma
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-A0070A	Liothyronine	Activator	99.82%	Unkown

Clinical Phase

Inhibitory Antibodies (17)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P9986	Tiragolumab	Inhibitor	99.04%	Phase 3
HY-P99858	Domvanalimab	Inhibitor	98.62%	Phase 3
HY-P990032	Belrestotug	Inhibitor	97%	Phase 3
HY-P990704	Rilvegostomig	Inhibitor	99.00%	Phase 3
HY-P99202	Vibostolimab	Inhibitor	96.54%	Phase 2
HY-P990960	Lucorafusp alfa		98.14%	Phase 2
HY-P990079	Renvistobart	Inhibitor	99.95%	Phase 2
HY-P990746	Lancastotug	Inhibitor	95.432%	Phase 2
HY-P990031	Dargistotug		99.36%	Phase 2
HY-P991394	SEA-TGT	Inhibitor	/	Phase 2
HY-P990030	Ralzapastotug	Inhibitor	98.67%	Phase 1
HY-P991389	BAT-6005	Inhibitor	95.89%	Phase 1
HY-P991386	PM-1021	Inhibitor	/	Phase 1
HY-P991390	BAT-6021	Inhibitor	/	Phase 1
HY-P991393	ASP8374		/	Phase 1
HY-P991620	JS006	Inhibitor	/	Phase 1
HY-P991391	COM902	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-185098	PD1-PDL1-IN-4	Inhibitor	/	Unkown
HY-A0070AS5	Liothyronine-d4		/	Unkown
HY-RS14524	TIGIT Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16565	Tigit Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22998	Tigit Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990155	Anti-Mouse TIGIT Antibody (1G9)	Inhibitor	99.71%	Unkown
HY-P992121	Nilvanstomig	Inhibitor	/	Unkown
HY-P991387	AGEN1307	Inhibitor	/	Unkown
HY-P991475	MG-1131		/	Unkown
HY-P992361	HB0030		/	Unkown
HY-P991111	Anti-Mouse TIGIT Antibody (10A7)	Inhibitor	98.37%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TIGIT	VGNC	VGNC:47374
Mus musculus	TIGIT	MGD	MGI:3642260
Felis catus	TIGIT	VGNC	VGNC:102853
Rattus norvegicus	TIGIT	RGD	RGD:1563191
Macaca mulatta	TIGIT	VGNC	VGNC:110333
Bos taurus	TIGIT	VGNC	VGNC:35868
Others	TIGIT	NCBI