TIGIT - T cell immunoreceptor with Ig and ITIM domains Gene

Homo sapiens

Also known as VSIG9; VSTM3; WUCAM

Gene ID: 201633 | Gene type: protein coding

About TIGIT

Cytogenetic location: 3q13.31 Genomic coordinates (GRCh38): 3:114,294,028-114,310,288 (from NCBI)

This gene has 7 transcripts (splice variants), 618 orthologues and 14 paralogues. Biased expression in lymph node (RPKM 15.1), spleen (RPKM 5.9) and 7 other tissues.

Summary

This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.[provided by RefSeq, Sep 2009]

TIGIT Products(1)

mRNA	Protein	Name
NM_173799.4	NP_776160.2	T-cell immunoreceptor with Ig and ITIM domains precursor

TIGIT Protein Structure

V-set

0
100
200
244 a.a.

Protein Preferred Names

Protein Names

T-cell immunoreceptor with Ig and ITIM domains

V-set and immunoglobulin domain containing 9

Recombinant TIGIT Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7414	TIGIT Protein, Human (HEK293, Fc)	Q495A1 (M22-P141)	≥95%
HY-P70624	TIGIT Protein, Human (120a.a, HEK293, His)	Q495A1 (M22-P141)	≥95%
HY-P70828	TIGIT, Human (HEK 293, Fc)	Q495A1 (M22-P141)	≥95%
HY-P71363	TIGIT Protein, Human (HEK293, mFc)	Q495A1 (M22-P141)	≥95%
HY-P72418	TIGIT Protein, Human (HEK293, His-Avi)	Q495A1-1 (M22-P141)	≥95%
HY-P73439	TIGIT Protein, Human (138a.a, HEK293, His)	Q495A1 (M1-F138)	≥95%
HY-P78216	TIGIT Protein, Human (Biotinylated, HEK293, His-Avi)	Q495A1 (M22-P141)	≥95%
HY-P78799	TIGIT Protein, Human (Biotinylated, HEK293, Fc-Avi)	Q495A1 (M22-P141)	≥95%

Related Diseases

Diseases

Alias

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Chromophobe Renal Cell Carcinoma

Chromophobe Adenocarcinoma	Chromophobe Carcinoma Of Kidney
Kidney Chromophobe	Renal Cell Carcinoma, Chromophobe Cell
Crcc	Chrcc
Chromophobe Renal Cell Adenocarcinoma	Chromophobe Renal Carcinoma
Chromophobe Carcinoma

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma	RCC
Nonpapillary Renal Cell Carcinoma	Clear Cell Renal Cell Carcinoma
Hypernephroma	Adenocarcinoma Of Kidney
Renal Carcinoma, Chromophobe, Somatic	Clear Cell Carcinoma Of Kidney
Clear-Cell Metastatic Renal Cell Carcinoma	Clear Cell Renal Carcinoma
Renal Cell Carcinoma, Somatic	Conventional Renal Cell Carcinoma
Conventional Renal Cell Carcinoma	Renal Clear Cell Carcinoma
Ccrcc	Hereditary Clear Cell Renal Cell Carcinoma
Carcinoma, Renal Cell	Renal Cell Carcinoma, Clear Cell, Somatic
Renal Cell Carcinoma, Clear Cell	Clear Cell Kidney Carcinoma
Clear Cell Rcc	Cystic-Multilocular Variant
Clear Cell Renal Cell Adenocarcinoma	Hereditary Clear Cell Renal Cell Adenocarcinoma
Common Renal Cell Carcinoma	Crcc
Renal Cell Carcinoma Non-Papillary	Carcinoma Renal Cell
Renal Cell Cancer	Carcinoma, Renal Cell, Nonpapillary

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14524	TIGIT Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TIGIT	VGNC	VGNC:47374
Mus musculus	TIGIT	MGD	MGI:3642260
Felis catus	TIGIT	VGNC	VGNC:102853
Rattus norvegicus	TIGIT	RGD	RGD:1563191
Macaca mulatta	TIGIT	VGNC	VGNC:110333
Bos taurus	TIGIT	VGNC	VGNC:35868
Macaca fascicularis	TIGIT	NCBI
Leporidae	TIGIT	NCBI
Others	TIGIT	NCBI

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