2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. Domvanalimab

Domvanalimab  (Synonyms: AB154)

Cat. No.: HY-P99858 Purity: 96.41%
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Domvanalimab (AB154) is an anti-TIGIT humanized monoclonal antibody. Domvanalimab binds human TIGIT9 and blocks the TIGIT-CD155 interaction. Domvanalimab can be used for studies of non-small cell lung cancer and esophageal cancer.

For research use only. We do not sell to patients.

CAS No. : 2368219-35-4

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Description

Domvanalimab (AB154) is an anti-TIGIT humanized monoclonal antibody. Domvanalimab binds human TIGIT9 and blocks the TIGIT-CD155 interaction. Domvanalimab can be used for studies of non-small cell lung cancer and esophageal cancer[1][2][3].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Humanized
In Vitro

Domvanalimab binds to and blocks human TIGIT with sub-nanomolar affinity in CHO cells over-expressing human TIGIT and human T cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Clinical Trial
Molecular Weight

145.12 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Domvanalimab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Domvanalimab2368219-35-4AB154AB 154AB-154Transmembrane GlycoproteinTIGIT9TIGIT-CD155cancerInhibitorinhibitorinhibit

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