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  4. Oncaspar

Oncaspar  (Synonyms: PEG-L-asparaginase; Pegasparaginase)

Art. -Nr.: HY-108860 Reinheit: 99.9%
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Oncaspar (PEG-L-asparaginase; Pegasparaginase), a pegylated form of native Escherichia coli-derived L-asparaginase, breaks down the amino acid asparagine that are circulating in the bloodstream. Oncaspar plays an important role in acute lymphoblastic leukemia (ALL) through asparagine hydrolysis and activation of the integrated stress response (ISR) pathway.

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Oncaspar

Oncaspar Chemische Struktur

CAS. Nr. : 130167-69-0

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Oncaspar Related Antibodies

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Beschreibung

Oncaspar (PEG-L-asparaginase; Pegasparaginase), a pegylated form of native Escherichia coli-derived L-asparaginase, breaks down the amino acid asparagine that are circulating in the bloodstream. Oncaspar plays an important role in acute lymphoblastic leukemia (ALL) through asparagine hydrolysis and activation of the integrated stress response (ISR) pathway[1].

In Vitro

Oncaspar (2 IU/mL, 48 h) inhibits the cell viability of 266-6, suppresses the expression of ATF3/4 proteins, and promotes the expression of FGF21 protein[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Oncaspar Related Antibodies

Cell Viability Assay[2]

Cell Line: 266-6
Concentration: 2 IU/mL
Incubation Time: 48 h
Result: Inhibited the cell viability.

Western Blot Analysis[2]

Cell Line: 266-6
Concentration: 2 IU/mL
Incubation Time: 48 h
Result: Downregulated the expression of ATF3 proteins, upregulated the expression of FGF21 protein.
In Vivo

Oncaspar (1 IU/g, intramuscular, single dose) causes edema and inflammatory infiltration in the pancreases of rats, induces inflammatory responses in Sprague-Dawley rats models[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats models[2]
Dosage: 1 IU/g
Administration: intramuscular, single dose
Result: Increased plasma lipase levels, inhibited the weight gain of rats, increased the levels of inflammatory markers IL6 and IL1β in pancreatic tissue, caused edema and inflammatory infiltration in the pancreases of rats.
Klinische Studie
Application

ELISA, FACS, Functional assay
Conjugated

Conjugated with pegol
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
CAS. Nr.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Oncaspar]
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation

Purity: 99.9%

SDS (251 KB)

COA (242 KB)

Inhibitory Antibodies User Guide (603 KB)
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Oncaspar Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oncaspar130167-69-0PEG-L-asparaginase PegasparaginaseFGFRInterleukin RelatedFibroblast growth factor receptorILlymphoblastic leukemia (ALL)L-asparaginasePEGInhibitorinhibitorinhibit

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