Oxyfedrine hydrochloride

Name: Oxyfedrine hydrochloride
Brand: MedChemExpress
SKU: HY-108300
Rating: 4.5 (0 reviews)

製品番号: HY-108300 純度: 99.92%: Data Sheet SDS COA 取扱説明書
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Technical Support

Oxyfedrine hydrochloride, a vasodilator, is an orally active β-adrenoreceptor agonist. Oxyfedrine decreases the tonicity of coronary vessels. Oxyfedrine hydrochloride can be used in the research of cardiovascular disease.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Oxyfedrine hydrochloride 構造式

CAS 番号 : 16777-42-7

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 275	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 275	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$250	在庫あり	Estimated Time of Arrival: December 31
10 mg	$420	在庫あり	Estimated Time of Arrival: December 31
25 mg	$650	在庫あり	Estimated Time of Arrival: December 31
50 mg	$940	在庫あり	Estimated Time of Arrival: December 31
100 mg	$1200	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Other Forms of Oxyfedrine hydrochloride:

Oxyfedrine お問い合わせ
Oxyfedrine hydrochloride (Standard) お問い合わせ

Adrenergic Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

α adrenergic receptor β adrenergic receptor

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

体外実験

Oxyfedrine (50 μM, 48 h) suppresses aldehyde dehydrogenase (ALDH) activity in HCT116 and HSC-4 cells^[1].
Oxyfedrine (50 μM, 48 h) acts as a sensitizer for GSH-depleting agents, and induces cell death in HCT116 and HSC-4 cells when with the drug combinations^[1].
Oxyfedrine (0-1 μg/mL) inhibits spontaneous myogenic activity in rat isolated portal vein^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Oxyfedrine (14 mg/kg, p.o., for 3-4 weeks) shows anti-anginal action in cats^[2].
Oxyfedrine (10 mg/kg, i.p., HCT116 cell xenograft mice) suppresses tumor growth when combined with sulfasalazine (SSZ, 350 mg/kg, i.p.)^[1].
Oxyfedrine (1 mg/kg, i.v.) decreases the arterial and venous blood high blood viscosity (HBV) in ice water stress rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

349.85

分子式

C₁₉H₂₄ClNO₃

CAS 番号

16777-42-7

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=CC(OC)=C1)CCN[C@@H](C)[C@H](O)C2=CC=CC=C2.[H]Cl

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶剤 & 溶解度

体外:

DMSO : 175 mg/mL (500.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8584 mL	14.2918 mL	28.5837 mL
5 mM	0.5717 mL	2.8584 mL	5.7167 mL
10 mM	0.2858 mL	1.4292 mL	2.8584 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.92%

Select Batch:

データシート (271 KB) SDS (251 KB)

COA (246 KB) HNMR (267 KB) RP-HPLC (244 KB) LCMS (93 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Otsuki Y, et al. Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy. Cancer Sci. 2020 Jan;111(1):127-136. [Content Brief]

[2]. Parratt JR. The haemodynamic effects of prolonged oral administration of oxyfedrine, a partial agonist at beta-adrenoceptors: comparison with propranolol. Br J Pharmacol. 1974 May;51(1):5-13. [Content Brief]

[3]. Yu J, et al. [Effects of oxyfedrine on high blood viscosity and myocardial necrosis induced by epinephrine and ice water stress in rats]. Zhongguo Yao Li Xue Bao. 1993 Jul;14(4):364-6. [Content Brief]

[4]. Mackenzie JE, et al. Effects of oxyfedrine on isolated portal vein and other smooth muscles. Br J Pharmacol. 1973 Apr;47(4):827-37. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8584 mL	14.2918 mL	28.5837 mL	71.4592 mL
	5 mM	0.5717 mL	2.8584 mL	5.7167 mL	14.2918 mL
	10 mM	0.2858 mL	1.4292 mL	2.8584 mL	7.1459 mL
	15 mM	0.1906 mL	0.9528 mL	1.9056 mL	4.7639 mL
	20 mM	0.1429 mL	0.7146 mL	1.4292 mL	3.5730 mL
	25 mM	0.1143 mL	0.5717 mL	1.1433 mL	2.8584 mL
	30 mM	0.0953 mL	0.4764 mL	0.9528 mL	2.3820 mL
	40 mM	0.0715 mL	0.3573 mL	0.7146 mL	1.7865 mL
	50 mM	0.0572 mL	0.2858 mL	0.5717 mL	1.4292 mL
	60 mM	0.0476 mL	0.2382 mL	0.4764 mL	1.1910 mL
	80 mM	0.0357 mL	0.1786 mL	0.3573 mL	0.8932 mL
	100 mM	0.0286 mL	0.1429 mL	0.2858 mL	0.7146 mL