p-SCN-Bn-NOTA trihydrochloride

Name: p-SCN-Bn-NOTA trihydrochloride
Brand: MedChemExpress
SKU: HY-W782083
Rating: 4.5 (0 reviews)

製品番号: HY-W782083 純度: 99.75%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

p-SCN-Bn-NOTA trihydrochloride is a macrocyclic chelator. p-SCN-Bn-NOTA trihydrochloride can be covalently coupled to molecules such as peptides through the thiocyanate group to form hexacoordinate copper (such as ⁶⁴Cu) complexes. p-SCN-Bn-NOTA trihydrochloride specifically binds to GRPR or EGFR highly expressed on the surface of tumor cells, mediating tumor enrichment of radioactive probes. p-SCN-Bn-NOTA trihydrochloride can be used to study malignant tumors expressing GRPR or EGFR, such as prostate cancer and colorectal cancer.

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p-SCN-Bn-NOTA trihydrochloride 構造式

CAS 番号 : 1583289-85-3

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 259	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 259	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$210	在庫あり	Estimated Time of Arrival: December 31
10 mg	$325	在庫あり	Estimated Time of Arrival: December 31
25 mg	$650	在庫あり	Estimated Time of Arrival: December 31
50 mg		お問い合わせ
100 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Radionuclide-Drug Conjugates (RDCs) アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

RDC Peptide RDC Antibody RDC Bifunctional Chelator RDC Linker Other

EGFR アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target

RDC Bifunctional Chelator

体内実験

⁶⁴Cu-NOTA-Bn-SCN-Aoc-BN(7-14) (0.5 MBq, 100 ng; i.v.) shows tumor-specific uptake in SCID mice bearing PC-3 xenografts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

559.89

分子式

C₂₀H₂₉Cl₃N₄O₆S

CAS 番号

1583289-85-3

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CN1C(CC2=CC=C(N=C=S)C=C2)CN(CC(O)=O)CCN(CC(O)=O)CC1.Cl.Cl.Cl

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (178.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7861 mL	8.9303 mL	17.8607 mL
5 mM	0.3572 mL	1.7861 mL	3.5721 mL
10 mM	0.1786 mL	0.8930 mL	1.7861 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.75%

Select Batch:

データシート (277 KB) SDS (394 KB)

COA (254 KB) HNMR (238 KB) RP-HPLC (242 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Craft JM, et al. In vitro and in vivo evaluation of a 64Cu-labeled NOTA-Bn-SCN-Aoc-bombesin analogue in gastrin-releasing peptide receptor expressing prostate cancer. Nucl Med Biol. 2012 Jul;39(5):609-16. [Content Brief]

[2]. Yun M, et al. A High-Affinity Repebody for Molecular Imaging of EGFR-Expressing Malignant Tumors. Theranostics. 2017 Jun 25;7(10):2620-2633. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7861 mL	8.9303 mL	17.8607 mL	44.6516 mL
	5 mM	0.3572 mL	1.7861 mL	3.5721 mL	8.9303 mL
	10 mM	0.1786 mL	0.8930 mL	1.7861 mL	4.4652 mL
	15 mM	0.1191 mL	0.5954 mL	1.1907 mL	2.9768 mL
	20 mM	0.0893 mL	0.4465 mL	0.8930 mL	2.2326 mL
	25 mM	0.0714 mL	0.3572 mL	0.7144 mL	1.7861 mL
	30 mM	0.0595 mL	0.2977 mL	0.5954 mL	1.4884 mL
	40 mM	0.0447 mL	0.2233 mL	0.4465 mL	1.1163 mL
	50 mM	0.0357 mL	0.1786 mL	0.3572 mL	0.8930 mL
	60 mM	0.0298 mL	0.1488 mL	0.2977 mL	0.7442 mL
	80 mM	0.0223 mL	0.1116 mL	0.2233 mL	0.5581 mL
	100 mM	0.0179 mL	0.0893 mL	0.1786 mL	0.4465 mL