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  4. Pelacarsen sodium

Pelacarsen sodium  (Synonyms: AKCEA-APO(a)-LRx sodium; ISIS 681257 sodium; TQJ230 sodium)

製品番号: HY-151123A 純度: 98.67%
COA 取扱説明書 Technical Support

Pelacarsen sodium (ISIS 681257 sodium) is a GalNAc3-conjugated 2′-MOE-modified antisense oligonucleotide. Pelacarsen sodium reduces apo (a).

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DNA, d([2′-O-(2-methoxyethyl)]m5rU-sp-[2′-O-(2-methoxyethyl)]rG-[2′-O-(2-methoxyethyl)]m5rC-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rC-m5C-sp-G-sp-T-sp-T-sp-G-sp-G-sp-T-sp-G-sp-m5C-sp-T-sp-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]rG-[2′-O-(2-methoxyethyl)]m5rU-sp-[2′-O-(2-methoxyethyl)]m5rU-sp-[2′-O-(2-methoxyethyl)]m5rC), 5′-[26-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[6-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]hexyl]amino]-3-oxopropoxy]methyl]-8,12,19-trioxo-16-oxa-7,13,20-triazahexacos-1-yl hydrogen phosphate], sodium salt

Pelacarsen sodium 構造式

CAS 番号 : 2172851-58-8

容量 価格（税別） 在庫状況 数量
1 mg $148 在庫あり
5 mg $396 在庫あり
10 mg $522 在庫あり
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Pelacarsen sodium 関連抗体

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Apolipoprotein アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
apoE apoB apoA1 apoA2 apoA4 apoC1 apoC2 apoC3

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

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製品説明

Pelacarsen sodium (ISIS 681257 sodium) is a GalNAc3-conjugated 2′-MOE-modified antisense oligonucleotide. Pelacarsen sodium reduces apo (a)[1][2][3].

体外実験

Pelacarsen (5-150 μg/mL) sodium has a high binding rate to mouse plasma proteins, 96.3% and 94.1% at 5 μg/mL and 150 μg/mL, respectively[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pelacarsen sodium 関連抗体
体内実験

Pelacarsen (0.3-10 mg/kg; s.c.; once weekly; 6 weeks) sodium reduces liver apo (a) mRNA and plasma apo (a) protein levels in human LPA transgenic mice, with over 20-fold higher potency than the unconjugated ISIS 494372[2].
Pelacarsen (1-12 mg/kg; s.c.) sodium in cynomolgus monkeys is rapidly absorbed[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Human LPA transgenic mice[2]
Dosage: 0.3, 1, 3, 10 mg/kg
Administration: Subcutaneous injection, once weekly, 6 weeks
Result: Showed dose-dependent reductions in liver apo(a) mRNA and plasma apo(a) protein levels.
Showed ED50 values of 0.32 mg/kg/week and 0.54 mg/kg/week for liver apo(a) mRNA and plasma apo(a) protein, respectively.
Animal Model: CD-1 mice[2]
Dosage: 4, 40, 140 mg/kg
Administration: Subcutaneous injection, loading doses on days 1, 3, 5, 7, then once weekly thereafter, up to 28 days
Result: Distributed rapidly to liver and kidney.
Showed a tissue elimination half-life of 6-9 days.
臨床実験
分子量

8636 (free acid)

分子式

C296H419N71Na20O163P20S13
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

[Pelacarsen (sodium)]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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参考文献
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pelacarsen2172851-58-8AKCEA-APO(a)-LRxISIS 681257TQJ230ISIS681257ISIS-681257TQJ 230TQJ-230ApolipoproteinDNA/RNA Synthesiscardiovascular diseaseslipoprotein disorderschronic kidney diseaseantisense oligonucleotideInhibitorinhibitorinhibit

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製品番号:
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