2172851-58-8
2172851-58-8
Chemical Structure
Pelacarsen sodium
Synonym(s): AKCEA-APO(a)-LRx sodium; ISIS 681257 sodium; TQJ230 sodium
- CAS No.: 2172851-58-8
- Formula:C296H419N71Na20O163P20S13
- Molecular Weight:8636 (free acid)
SMILES: [Pelacarsen (sodium)]
Biological Activity: Pelacarsen sodium (ISIS 681257 sodium) is a GalNAc3-conjugated 2′-MOE-modified antisense oligonucleotide. Pelacarsen sodium reduces apo (a)[1][2][3].
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Pelacarsen sodium | 98.67% | Pelacarsen sodium (ISIS 681257 sodium) is a GalNAc3-conjugated 2′-MOE-modified antisense oligonucleotide. Pelacarsen sodium reduces apo (a). | ||||||||||||||||||||
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References
- [1]. Yeang C, et al. Effect of Pelacarsen on Lipoprotein(a) Cholesterol and Corrected Low-Density Lipoprotein Cholesterol. J Am Coll Cardiol. 2022 Mar 22;79(11):1035-1046. [Content Brief]
- [2]. Yu RZ, Graham MJ, Post N, et al. Disposition and Pharmacology of a GalNAc3-conjugated ASO Targeting Human Lipoprotein (a) in Mice. Mol Ther Nucleic Acids. 2016;5(5):e317. [Content Brief]
- [3]. Yu RZ, Gunawan R, Post N, et al. Disposition and Pharmacokinetics of a GalNAc3-Conjugated Antisense Oligonucleotide Targeting Human Lipoprotein (a) in Monkeys. Nucleic Acid Ther. 2016;26(6):372-380. [Content Brief]
Keywords
