Pentosidine 

Pentosidine is a fluorescent advanced glycation end product (AGE) and cross-linker. Pentosidine is a fluorescent cross-linked structure formed by lysine and arginine in sugar oxidation reactions, and it is commonly found in collagen, skin, bone, lens and plasma proteins. Pentosidine is used in research related to type 1 diabetes, brown cataracts, rheumatoid arthritis, atherosclerosis and neurodegenerative diseases^[1][2].

Pentosidine (equimolar pentoses; 6 days at 37 °C) forms in young human dura mater collagen incubated with pentoses at 37 °C for 6 days, with ribose driving the most robust formation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pentosidine is a molecular marker of cumulative protein damage in diabetes, aging and uremia^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

378.43

C₁₇H₂₆N₆O₄

124505-87-9

OC([C@@H](N)CCCCN1C2=NC(NCCC[C@H](N)C(O)=O)=NC2=CC=C1)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sell DR, et al. Pentosidine: a molecular marker for the cumulative damage to proteins in diabetes, aging, and uremia. Diabetes Metab Rev. 1991;7(4):239-251.  [Content Brief]

  [2]. Requena JR, et al. Measurement of pentosidine in biological samples. Methods Mol Med. 2000;38:209-217.  [Content Brief]