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Cat. No.: HY-113033A

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Pentosidine TFA

Pentosidine TFA is a fluorescent advanced glycation end product (AGE) and cross-linker. Pentosidine TFA is a fluorescent cross-linked structure formed by lysine and arginine in sugar oxidation reactions, and it is commonly found in collagen, skin, bone, lens and plasma proteins. Pentosidine TFA is used in research related to type 1 diabetes, brown cataracts, rheumatoid arthritis, atherosclerosis and neurodegenerative diseases.

For research use only. We do not sell to patients.

CAS No.: 225784-09-8
Formula: C₁₉H₂₇F₃N₆O₆
Molecular Weight:492.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Pentosidine TFA Chemical Structure

CAS No.: 225784-09-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

Pentosidine (equimolar pentoses; 6 days at 37 °C) TFA forms in young human dura mater collagen incubated with pentoses at 37 °C for 6 days, with ribose driving the most robust formation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pentosidine TFA is a molecular marker of cumulative protein damage in diabetes, aging and uremia^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 225784-09-8
Molecular Weight 492.45
Formula C₁₉H₂₇F₃N₆O₆
SMILES

OC(C(F)(F)F)=O.OC([C@@H](N)CCCCN1C2=NC(NCCC[C@H](N)C(O)=O)=NC2=CC=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sell DR, et al. Pentosidine: a molecular marker for the cumulative damage to proteins in diabetes, aging, and uremia. Diabetes Metab Rev. 1991;7(4):239-251. [Content Brief]

[2]. Requena JR, et al. Measurement of pentosidine in biological samples. Methods Mol Med. 2000;38:209-217. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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