225784-09-8
Chemical Structure
Pentosidine TFA
- CAS No.: 225784-09-8
- Formula:C19H27F3N6O6
- Molecular Weight:492.45
InChIKey: LBSRBPSBZIUCMG-FXMYHANSSA-N
SMILES: OC(C(F)(F)F)=O.OC([C@@H](N)CCCCN1C2=NC(NCCC[C@H](N)C(O)=O)=NC2=CC=C1)=O
Biological Activity: Pentosidine TFA is a fluorescent advanced glycation end product (AGE) and cross-linker. Pentosidine TFA is a fluorescent cross-linked structure formed by lysine and arginine in sugar oxidation reactions, and it is commonly found in collagen, skin, bone, lens and plasma proteins. Pentosidine TFA is used in research related to type 1 diabetes, brown cataracts, rheumatoid arthritis, atherosclerosis and neurodegenerative diseases[1][2].
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Pentosidine TFA | Pentosidine TFA is a fluorescent advanced glycation end product (AGE) and cross-linker. Pentosidine TFA is a fluorescent cross-linked structure formed by lysine and arginine in sugar oxidation reactions, and it is commonly found in collagen, skin, bone, lens and plasma proteins. Pentosidine TFA is used in research related to type 1 diabetes, brown cataracts, rheumatoid arthritis, atherosclerosis and neurodegenerative diseases. | |||||||||||||||||||||
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- [1]. Sell DR, et al. Pentosidine: a molecular marker for the cumulative damage to proteins in diabetes, aging, and uremia. Diabetes Metab Rev. 1991;7(4):239-251. [Content Brief]
- [2]. Requena JR, et al. Measurement of pentosidine in biological samples. Methods Mol Med. 2000;38:209-217. [Content Brief]
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