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  4. Pentosidine

Pentosidine is a fluorescent advanced glycation end product (AGE) and cross-linker. Pentosidine is a fluorescent cross-linked structure formed by lysine and arginine in sugar oxidation reactions, and it is commonly found in collagen, skin, bone, lens and plasma proteins. Pentosidine is used in research related to type 1 diabetes, brown cataracts, rheumatoid arthritis, atherosclerosis and neurodegenerative diseases.

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Pentosidine

Pentosidine Chemical Structure

CAS No. : 124505-87-9

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Other Forms of Pentosidine:

Pentosidine Related Antibodies

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Description

Pentosidine is a fluorescent advanced glycation end product (AGE) and cross-linker. Pentosidine is a fluorescent cross-linked structure formed by lysine and arginine in sugar oxidation reactions, and it is commonly found in collagen, skin, bone, lens and plasma proteins. Pentosidine is used in research related to type 1 diabetes, brown cataracts, rheumatoid arthritis, atherosclerosis and neurodegenerative diseases[1][2].

In Vitro

Pentosidine (equimolar pentoses; 6 days at 37 °C) forms in young human dura mater collagen incubated with pentoses at 37 °C for 6 days, with ribose driving the most robust formation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pentosidine Related Antibodies
In Vivo

Pentosidine is a molecular marker of cumulative protein damage in diabetes, aging and uremia[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

378.43

Formula

C17H26N6O4
CAS No.
SMILES

OC([C@@H](N)CCCCN1C2=NC(NCCC[C@H](N)C(O)=O)=NC2=CC=C1)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Pentosidine Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pentosidine124505-87-9OthersBiochemical Assay Reagentstype 1 diabetesend-stage renal diseaseadvanced glycation end-productlysinerheumatoid arthritisarginineuremialens crystallinhuman skinatherosclerosisInhibitorinhibitorinhibit

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