2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR Dopamine Transporter GABA Receptor iGluR
  4. Phenylpiracetam

Phenylpiracetam  (Synonyms: Carphedon)

製品番号: HY-14840 純度: 99.83%
COA 取扱説明書 Technical Support

Phenylpiracetam (Carphedon) is a positive allosteric modulator of nicotinic acetylcholine receptors (nAChR) with an IC50 of 5.86 μM. Phenylpiracetam is applicable to studies on scopolamine (Scopolamine) (HY-N0296)-induced amnesia, depression and immune stress.

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Phenylpiracetam

Phenylpiracetam 構造式

CAS 番号 : 77472-70-9

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 在庫あり
Solution
10 mM * 1 mL in DMSO USD 55 在庫あり
Solid
5 mg $50 在庫あり
10 mg $60 在庫あり
50 mg $80 在庫あり
100 mg $90 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Other Forms of Phenylpiracetam:

Phenylpiracetam 関連抗体

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製品説明

Phenylpiracetam (Carphedon) is a positive allosteric modulator of nicotinic acetylcholine receptors (nAChR) with an IC50 of 5.86 μM. Phenylpiracetam is applicable to studies on scopolamine (Scopolamine) (HY-N0296)-induced amnesia, depression and immune stress[1][2].

体外実験

Phenylpiracetam directly interacts with mouse brain cortex α4β2 nicotinic acetylcholine receptors with an IC50 of 5.86 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Phenylpiracetam 関連抗体
体内実験

Phenylpiracetam (100 mg/kg; i.p.; single dose) attenuates scopolamine-induced amnesia in male Wistar rats by normalizing densities of striatal D1, cortical nicotinic acetylcholine, and cortical benzodiazepine receptors, partially reducing hippocampal NMDA receptor density, and increasing striatal D2 receptor density by 29% relative to controls[1].
Phenotropil (25 mg/kg; i.p.; daily; 5 days) exerts a strong psychoimmunomodulatory effect in LPS-induced immune stress in Wistar rats, normalizing key cellular and innate immune parameters while improving locomotor, exploratory, and anxiety-related behaviors without altering antibody production[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar (male, 180-220 g, scopolamine-induced amnesia)[1]
Dosage: 100 mg/kg
Administration: i.p.; single dose
Result: Increased 24-hour post-training latency to enter the dark compartment to 78.0 seconds, attenuating scopolamine-induced amnesia.
Normalized striatal dopamine D1 receptor density to 264.8 fmol/mg protein, abolishing scopolamine-induced reduction.
Increased striatal dopamine D2 receptor density to 367.9 fmol/mg protein, a 29% increase vs.
control.
Increased striatal dopamine D3 receptor density to 70.15 fmol/mg protein.
Reduced hippocampal NMDA receptor density to 4002 fmol/mg protein, a 24% reduction vs.
scopolamine-treated rats.
Normalized cortical nicotinic acetylcholine receptor density to 278 ± 73 fmol/mg protein, abolishing scopolamine-induced elevation.
Normalized cortical benzodiazepine receptor density to 2.62 fmol/mg protein, abolishing scopolamine-induced reduction.
Caused no changes in serotonin 5-HT2 receptor density.
Animal Model: Wistar rats (male and female, 250-300 g, LPS-induced immune stress)[2]
Dosage: 25 mg/kg
Administration: i.p.; daily; 5 days
Result: Restored cellular immunity and nonspecific resistance.
Reduced delayed-type hypersensitivity reaction index, phagocytic index, and phagocytic number to levels not significantly different from normal control rats.
Left anti-erythrocyte antibody titer elevated (no effect on antibody production observed).
Prevented anxiety, fear, and sluggishness.
Increased horizontal locomotion, vertical rearing postures, crossing of the open field central area, maze arm transitions, hole exploration, hanging out from open maze arms, and exploration episodes of looking out from closed maze arms.
分子量

218.25

分子式

C12H14N2O2
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(N)CN1C(CC(C2=CC=CC=C2)C1)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : ≥ 100 mg/mL (458.19 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5819 mL 22.9095 mL 45.8190 mL
5 mM 0.9164 mL 4.5819 mL 9.1638 mL
10 mM 0.4582 mL 2.2910 mL 4.5819 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (11.45 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (11.45 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション

純度: 99.91%

COA (252 KB) HNMR (155 KB) LCMS (100 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.5819 mL 22.9095 mL 45.8190 mL 114.5475 mL
5 mM 0.9164 mL 4.5819 mL 9.1638 mL 22.9095 mL
10 mM 0.4582 mL 2.2910 mL 4.5819 mL 11.4548 mL
15 mM 0.3055 mL 1.5273 mL 3.0546 mL 7.6365 mL
20 mM 0.2291 mL 1.1455 mL 2.2910 mL 5.7274 mL
25 mM 0.1833 mL 0.9164 mL 1.8328 mL 4.5819 mL
30 mM 0.1527 mL 0.7637 mL 1.5273 mL 3.8183 mL
40 mM 0.1145 mL 0.5727 mL 1.1455 mL 2.8637 mL
50 mM 0.0916 mL 0.4582 mL 0.9164 mL 2.2910 mL
60 mM 0.0764 mL 0.3818 mL 0.7637 mL 1.9091 mL
80 mM 0.0573 mL 0.2864 mL 0.5727 mL 1.4318 mL
100 mM 0.0458 mL 0.2291 mL 0.4582 mL 1.1455 mL
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Phenylpiracetam Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phenylpiracetam77472-70-9CarphedonnAChRDopamine TransporterGABA ReceptoriGluRNicotinic acetylcholine receptorsDATSLC6A3Gamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorIonotropic glutamate receptorsGABA-A receptor benzodiazepine siteimmune stressdopamine D3 receptorsmouse brain cortex α4β2 nicotinic acetylcholine receptorsdopamine D2 receptorsglutamate NMDA receptorsdopamine D1 receptorsscopolamine-induced amnesiarat brain regionsmouse nicotinic acetylcholine receptorsInhibitorinhibitorinhibit

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