(R)-Phenylpiracetam
(R)-Phenylpiracetam (MRZ 9547) is a dopamine transporter (DAT) inhibitor (Ki: 14.8 μM; IC50: 65.5 μM). (R)-Phenylpiracetam can be used for the research of the neurological or neuropsychiatric disorders.
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- CAS No.: 949925-07-9
- Formule: C12H14N2O2
- Masse moléculaire:218.25
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Ki: 14.8 μM (DAT); IC50: 65.5 μM (DAT)[2]
(R)-Phenylpiracetam displaces the binding of [125I] RTI-55 (IC50 = 4.82 μM) to human recombinant DAT expressed in CHO-K1 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
(R)-Phenylpiracetam (10, 25, 50 mg/kg; p.o.; pretreatment for 7 days) dose-dependently reduces paw oedema and the antinociceptive response on carrageenan induced mouse[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 949925-07-9
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Masse moléculaire 218.25
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Formule C12H14N2O2
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SMILES
O=C(N)CN1C(C[C@H](C2=CC=CC=C2)C1)=O
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Synonyms
MRZ 9547
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Zvejniece L, et al. Neuroprotective and anti-inflammatory activity of DAT inhibitor R-phenylpiracetam in experimental models of inflammation in male mice. Inflammopharmacology. 2020;28(5):1283-1292. [Content Brief]
[2]. Sommer S, et al. The dopamine reuptake inhibitor MRZ-9547 increases progressive ratio responding in rats. Int J Neuropsychopharmacol. 2014;17(12):2045-2056. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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