1. Anti-infection
  2. Fungal
  3. Polygodial

Polygodial (Synonyms: Poligodial; Tadeonal)

Cat. No.: HY-108450
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Polygodial (Poligodial) is an antifungal potentiator. Polygodial is a sesquiterpene with anti-hyperalgesic properties.

For research use only. We do not sell to patients.

Polygodial Chemical Structure

Polygodial Chemical Structure

CAS No. : 6754-20-7

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Description

Polygodial (Poligodial) is an antifungal potentiator[1]. Polygodial is a sesquiterpene with anti-hyperalgesic properties[2].

In Vitro

Polygodial exhibits fungicidal activity against Saccharomyces cerevisiaeCandida albicans, and other fungal pathogens in standardized susceptibility tests (NCCLS). Polygodial (12.5 μg/mL, 3 hours) induces significant shrinkage compared to controls in Saccharomyces cerevisiae cells with the minimum fungicidal concentration (MFC) for 106 CFU/mL in RPMI 1640 medium[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: S. cerevisiae cells
Concentration: 12.5 μg/mL
Incubation Time: 3 hours
Result: Treated cells exhibited significant shrinkage compared to controls, and the organization of subcellular organelles appears either disrupted or compacted.
In Vivo

Polygodial is a sesquiterpene isolated from the barks of Drymis winteri (Winteraceae). Polygodial (0.5 to 10 mg/kg; 0.5 h; given by i.p. route to mice) induces significant, dose-related and almost complete inhibition of Acetic acid, Kaolin and Zymosan-induced abdominal constrictions. The calculated mean ID50 values are 0.8, 2.1 and 2.6 mg/kg and maximal inhibitions of 90.0±3.0, 98.0±1.0 and 97.0±2.0 %, against Acetic acid, Kaolin and Zymosan, respectively. Polygodial is about 14- to 27-fold more potent than the hydroalcoholic extract (HE) at the ID50 level[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Non-fasted male Swiss mice (20-30 g) or male Wistar rats (150-180 g)[2]
Dosage: 0.1 to 10 mg/kg
Administration: Injected i.p. 0.5 h before the injection of irritant substances
Result: Produced significant inhibition of Acetic acid, Kaolin and Zymosan-induced writhing in mice.
Molecular Weight

234.33

Formula

C₁₅H₂₂O₂

CAS No.
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Polygodial
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