2. Anti-infection
  3. Fungal
  4. Polygodial

Polygodial  (Synonyms: Poligodial; Tadeonal)

Cat. No.: HY-108450 Purity: 99.45%
COA Handling Instructions

Polygodial (Poligodial) is an antifungal potentiator. Polygodial is a sesquiterpene with anti-hyperalgesic properties.

For research use only. We do not sell to patients.

Polygodial Chemical Structure

Polygodial Chemical Structure

CAS No. : 6754-20-7

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5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 380 In-stock
Estimated Time of Arrival: December 31
25 mg USD 750 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Polygodial (Poligodial) is an antifungal potentiator[1]. Polygodial is a sesquiterpene with anti-hyperalgesic properties[2].

In Vitro

Polygodial exhibits fungicidal activity against Saccharomyces cerevisiae, Candida albicans, and other fungal pathogens in standardized susceptibility tests (NCCLS). Polygodial (12.5 μg/mL, 3 hours) induces significant shrinkage compared to controls in Saccharomyces cerevisiae cells with the minimum fungicidal concentration (MFC) for 106 CFU/mL in RPMI 1640 medium[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: S. cerevisiae cells
Concentration: 12.5 μg/mL
Incubation Time: 3 hours
Result: Treated cells exhibited significant shrinkage compared to controls, and the organization of subcellular organelles appears either disrupted or compacted.
In Vivo

Polygodial is a sesquiterpene isolated from the barks of Drymis winteri (Winteraceae). Polygodial (0.5 to 10 mg/kg; 0.5 h; given by i.p. route to mice) induces significant, dose-related and almost complete inhibition of Acetic acid, Kaolin and Zymosan-induced abdominal constrictions. The calculated mean ID50 values are 0.8, 2.1 and 2.6 mg/kg and maximal inhibitions of 90.0±3.0, 98.0±1.0 and 97.0±2.0 %, against Acetic acid, Kaolin and Zymosan, respectively. Polygodial is about 14- to 27-fold more potent than the hydroalcoholic extract (HE) at the ID50 level[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Non-fasted male Swiss mice (20-30 g) or male Wistar rats (150-180 g)[2]
Dosage: 0.1 to 10 mg/kg
Administration: Injected i.p. 0.5 h before the injection of irritant substances
Result: Produced significant inhibition of Acetic acid, Kaolin and Zymosan-induced writhing in mice.
Molecular Weight

234.33

Appearance

Solid

Formula

C15H22O2
CAS No.
SMILES

O=C[[email protected]]1C(C=O)=CC[[email protected]@]2([H])C(C)(C)CCC[[email protected]]12C
Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (426.75 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2675 mL 21.3374 mL 42.6749 mL
5 mM 0.8535 mL 4.2675 mL 8.5350 mL
10 mM 0.4267 mL 2.1337 mL 4.2675 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (10.67 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (10.67 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (10.67 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Polygodial6754-20-7Poligodial TadeonalFungalAntifungal,Potentiator,sesquiterpene,anti-hyperalgesicInhibitorinhibitorinhibit

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