Pozanicline dihydrochloride (Synonyms: ABT-089 dihydrochloride)

Name: Pozanicline dihydrochloride
Brand: MedChemExpress
SKU: HY-110160
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Cat. No.: HY-110160 Pureza: 99.06%: Ficha de datos
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Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable nicotinic acetylcholine receptor (nAChR) agonist with a K_i of 16.7 nM for binding to [³H]cytisine sites. Pozanicline is an α4β2-selective nAChR agonist, which binds to rat brain α4β2 nAChR with a K_i of 17 nM while binding to α7 nAChR is insignificant.

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Pozanicline dihydrochloride Estructura química

No. CAS : 161416-61-1

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	En stock	Estimated Time of Arrival: December 31
Solid
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

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Descripciòn

Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable nicotinic acetylcholine receptor (nAChR) agonist with a K_i of 16.7 nM for binding to [³H]cytisine sites^[1]. Pozanicline is an α4β2-selective nAChR agonist, which binds to rat brain α4β2 nAChR with a K_i of 17 nM while binding to α7 nAChR is insignificant^[2].

In Vitro

Pozanicline (ABT-089) is a partial agonist at α4β2 nAChR. Moreover, one α6β2 nAChR subtype is particularly sensitive to Pozanicline with an EC₅₀ of 0.11 μM^[2].
Pozanicline (ABT-089) shows high selectivity for α6β2 and α4α5β2 nAChR subtypes^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pozanicline (ABT-089; 0.3 mg/kg and 0.6 mg/kg) reverses nicotine withdrawal-induced deficits in contextual fear conditioning^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult male C57BL6/J mice at 8-12 weeks of age^[3].
Dosage:	0.3 mg/kg and 0.6 mg/kg
Administration:	Treated 5 min before training and testing for contextual fear conditioning
Result:	A dose of 0.3 mg/kg and 0.6 mg/kg ameliorated nicotine withdrawal-induced cognitive deficits in contextual fear conditioning.

Ensayo clínico

Peso molecular

265.18

Fòrmula

C₁₁H₁₈Cl₂N₂O

No. CAS

161416-61-1

Appearance

Solid

Color

White to off-white

SMILES

[H]Cl.[H]Cl.CC(N=CC=C1)=C1OC[C@@H]2CCCN2

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad

In Vitro:

H₂O : 100 mg/mL (377.10 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7710 mL	18.8551 mL	37.7102 mL
5 mM	0.7542 mL	3.7710 mL	7.5420 mL
10 mM	0.3771 mL	1.8855 mL	3.7710 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (377.10 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureza y Documentación

Purity: 99.06%

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Ficha de datos (275 KB) SDS (393 KB)

COA (250 KB) LCMS (101 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Lin NH, et al. Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties. J Med Chem. 1997 Jan 31;40(3):385-90 [Content Brief]

[2]. Marks MJ, et al. Selectivity of ABT-089 for α4β2 and α6β2 nicotinic acetylcholine receptors in brain. Biochem Pharmacol. 2009 Oct 1;78(7):795-802. [Content Brief]

[3]. Yildirim E, et al. ABT-089, but not ABT-107, ameliorates nicotine withdrawal-induced cognitive deficits in C57BL6/J mice. Behav Pharmacol. 2015 Apr;26(3):241-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.7710 mL	18.8551 mL	37.7102 mL	94.2756 mL
	5 mM	0.7542 mL	3.7710 mL	7.5420 mL	18.8551 mL
	10 mM	0.3771 mL	1.8855 mL	3.7710 mL	9.4276 mL
	15 mM	0.2514 mL	1.2570 mL	2.5140 mL	6.2850 mL
	20 mM	0.1886 mL	0.9428 mL	1.8855 mL	4.7138 mL
	25 mM	0.1508 mL	0.7542 mL	1.5084 mL	3.7710 mL
	30 mM	0.1257 mL	0.6285 mL	1.2570 mL	3.1425 mL
	40 mM	0.0943 mL	0.4714 mL	0.9428 mL	2.3569 mL
	50 mM	0.0754 mL	0.3771 mL	0.7542 mL	1.8855 mL
	60 mM	0.0629 mL	0.3143 mL	0.6285 mL	1.5713 mL
	80 mM	0.0471 mL	0.2357 mL	0.4714 mL	1.1784 mL
	100 mM	0.0377 mL	0.1886 mL	0.3771 mL	0.9428 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Pozanicline dihydrochloride Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pozanicline161416-61-1ABT-089ABT089ABT 089nAChRNicotinic acetylcholine receptorsParkinsonAlzheimerdiseasenicotinicacetylcholinereceptordopamineInhibitorinhibitorinhibit

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Pozanicline dihydrochloride (Synonyms: ABT-089 dihydrochloride)

Revisión del cliente

Other Forms of Pozanicline dihydrochloride:

Pozanicline dihydrochloride Related Antibodies

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Actividad biológica

Pureza y Documentación

Referencias

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Pozanicline dihydrochloride Related Antibodies

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Complete Stock Solution Preparation Table

Pozanicline dihydrochloride Related Classifications

Keywords:

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