1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. Pozanicline

Pozanicline (Synonyms: ABT-089)

Cat. No.: HY-14565
Handling Instructions

Pozanicline (ABT-089) selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes, is a novel cholinergic agent that is a partial agonist at α4β2* nAChRs (Ki=16 nM) and shows high selectivity for α6β2* and α4α5β2 nAChR subtypes, the binding affinity (Ki, rat) for Pozanicline to [3H] cytisine sites is 16.7 nM. Pozanicline reverses nicotine withdrawal-induced cognitive deficits, may be an effective component of novel therapeutic strategies for nicotine addiction.

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Pozanicline Chemical Structure

Pozanicline Chemical Structure

CAS No. : 161417-03-4

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Description

Pozanicline (ABT-089) selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes, is a novel cholinergic agent that is a partial agonist at α4β2* nAChRs (Ki=16 nM) and shows high selectivity for α6β2* and α4α5β2 nAChR subtypes, the binding affinity (Ki, rat) for Pozanicline to [3H] cytisine sites is 16.7 nM. Pozanicline reverses nicotine withdrawal-induced cognitive deficits, may be an effective component of novel therapeutic strategies for nicotine addiction[1].

IC50 & Target

Ki: 16 nM (α4β2* nAChR)[1]

Molecular Weight

192.26

Formula

C₁₁H₁₆N₂O

CAS No.

161417-03-4

SMILES

CC1=C(OC[[email protected]]2NCCC2)C=CC=N1

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Storage

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Keywords:

PozaniclineABT-089ABT089ABT 089nAChRNicotinic acetylcholine receptorsInhibitorinhibitorinhibit

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