161417-03-4
Chemical Structure
Pozanicline
Synonym(s): ABT-089
- CAS No.: 161417-03-4
- Formula:C11H16N2O
- Molecular Weight:192.26
IUPAC Name: (S)-2-methyl-3-(pyrrolidin-2-ylmethoxy)pyridine
InChIKey: YRVIKLBSVVNSHF-JTQLQIEISA-N
SMILES: CC1=C(OC[C@H]2NCCC2)C=CC=N1
Biological Activity: Pozanicline (ABT-089) selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes, is a novel cholinergic agent that is a partial agonist at α4β2* nAChRs (Ki=16 nM) and shows high selectivity for α6β2* and α4α5β2 nAChR subtypes, the binding affinity (Ki, rat) for Pozanicline to [3H] cytisine sites is 16.7 nM. Pozanicline reverses nicotine withdrawal-induced cognitive deficits, may be an effective component of novel therapeutic strategies for nicotine addiction[1].
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Pozanicline | Pozanicline (ABT-089) selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes, is a novel cholinergic agent that is a partial agonist at α4β2* nAChRs (Ki=16 nM) and shows high selectivity for α6β2* and α4α5β2 nAChR subtypes, the binding affinity (Ki, rat) for Pozanicline to [3H] cytisine sites is 16.7 nM. Pozanicline reverses nicotine withdrawal-induced cognitive deficits, may be an effective component of novel therapeutic strategies for nicotine addiction. | |||||||||||||||||||||
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Keywords
