1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. Pozanicline dihydrochloride

Pozanicline dihydrochloride (Synonyms: ABT-089 dihydrochloride)

Cat. No.: HY-110160
Handling Instructions

Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable nicotinic acetylcholine receptor (nAChR) agonist with a Ki of 16.7 nM for binding to [3H]cytisine sites. Pozanicline is an α4β2-selective nAChR agonist, which binds to rat brain α4β2 nAChR with a Ki of 17 nM while binding to α7 nAChR is insignificant.

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Pozanicline dihydrochloride Chemical Structure

Pozanicline dihydrochloride Chemical Structure

CAS No. : 161416-61-1

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Based on 1 publication(s) in Google Scholar

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Description

Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable nicotinic acetylcholine receptor (nAChR) agonist with a Ki of 16.7 nM for binding to [3H]cytisine sites[1]. Pozanicline is an α4β2-selective nAChR agonist, which binds to rat brain α4β2 nAChR with a Ki of 17 nM while binding to α7 nAChR is insignificant[2].

In Vitro

Pozanicline (ABT-089) is a partial agonist at α4β2 nAChR. Moreover, one α6β2 nAChR subtype is particularly sensitive to Pozanicline with an EC50 of 0.11 μM[2].
Pozanicline (ABT-089) shows high selectivity for α6β2 and α4α5β2 nAChR subtypes[3].

In Vivo

Pozanicline (ABT-089; 0.3 mg/kg and 0.6 mg/kg) reverses nicotine withdrawal-induced deficits in contextual fear conditioning[3].

Animal Model: Adult male C57BL6/J mice at 8-12 weeks of age[3].
Dosage: 0.3 mg/kg and 0.6 mg/kg
Administration: Treated 5 min before training and testing for contextual fear conditioning
Result: A dose of 0.3 mg/kg and 0.6 mg/kg ameliorated nicotine withdrawal-induced cognitive deficits in contextual fear conditioning.
Molecular Weight

265.18

Formula

C₁₁H₁₈Cl₂N₂O

CAS No.

161416-61-1

SMILES

[H]Cl.[H]Cl.CC(N=CC=C1)=C1OC[[email protected]@H]2CCCN2

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PozaniclineABT-089ABT089ABT 089nAChRNicotinic acetylcholine receptorsParkinsonAlzheimerdiseasenicotinicacetylcholinereceptordopamineInhibitorinhibitorinhibit

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Pozanicline dihydrochloride
Cat. No.:
HY-110160
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