1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. EGF superfamily
  4. ERBB3

The receptor tyrosine-protein kinase ErbB3 (HER3) is a member of the epidermal growth factor receptor (EGFR) family, which also includes EGFR (ErbB1), ErbB2 (HER2/neu), and ErbB4 (HER4). Unlike other members in the family, ErbB3 lacks or has impaired kinase activity, therefore ERBB3 homodimers possess little autophosphorylation activity, albeit some is present. However, ERBB3 can still be phosphorylated and induce potent downstream signaling. To transduce cell signaling, ErbB3 has to interact with other EGF receptor family members and to be phosphorylated its interactive partners, of those, ErbB2 is the most important one. The primary ligands for ERBB3 are the members of the Neuregulins (NRG, HRG) family. Downstream it interacts prominently with the phosphoinositol 3-kinase/AKT survival/mitogenic pathway, but also with GRB, SHC, SRC, ABL, rasGAP, SYK and the transcription regulator EBP1. Amplification of ERBB3 gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors.

Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name Effect Purity