S-1-Propenyl-L-cysteine

Name: S-1-Propenyl-L-cysteine
Brand: MedChemExpress
SKU: HY-111827
Rating: 5.0 (6 reviews)

Cat. No.: HY-111827 Pureza: 99.91%: Ficha de datos
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S-1-Propenyl-L-cysteine is a stereoisomer of S-allyl-l-cysteine, extracted from garlic, with immunomodulatory effects and reduces blood pressure in a hypertensive animal model. S-1-Propenyl-L-cysteine exhibits antioxidative efficacy through a NO-dependent BACH1 signaling pathway. S-1-Propenyl-L-cysteine is orally active.

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S-1-Propenyl-L-cysteine Estructura química

No. CAS : 52438-09-2

Tamaño	Stock	Cantidad
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

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Revisión del cliente

Based on 6 publication(s) in Google Scholar

Other Forms of S-1-Propenyl-L-cysteine:

S-1-Propenyl-L-cysteine (Standard) Obtener un presupuesto

6 Publications Citing Use of MCE S-1-Propenyl-L-cysteine

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Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

S-1-Propenyl-L-cysteine is a stereoisomer of S-allyl-l-cysteine, extracted from garlic, with immunomodulatory effects and reduces blood pressure in a hypertensive animal model^[1]. S-1-Propenyl-L-cysteine exhibits antioxidative efficacy through a NO-dependent BACH1 signaling pathway^[2]. S-1-Propenyl-L-cysteine is orally active.

In Vitro

S-1-Propenyl-L-cysteine NO-dependently upregulates levels of HMOX1, which causes the downregulation of BACH1, leads to a BACH1-degradation in nucleus^[2].
S-1-Propenyl-L-cysteine inhibites lipopolysaccharides (LPS)-induced TLR4 signaling pathway by inducing MyD88 degradation through its denaturation and the activation of autophagy^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[2]

Cell Line:	HUEVCs
Concentration:	0-50 μM
Incubation Time:	24 h
Result:	Increased expression of HMOX1 and decreased levels of BACH1 with prescence of NOR3.

Western Blot Analysis^[4]

Cell Line:	splenic lymphocytes
Concentration:	0.3 mM
Incubation Time:	20 min
Result:	Increased levels of pAMPK, decreased levels of p-IRAK4 and NF-kB p65.

In Vivo

S-1-Propenyl-L-cysteine (6.5 mg/kg, p.o.) reduces systolic blood pressure (SBP), alters histidine metabolism and exerts the antihypertensive effect via the central histamine H3 receptor in spontaneously hypertensive rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	spontaneously hypertensive rats (SHR) ^[3]
Dosage:	6.5  mg/kg
Administration:	p.o., single dosage
Result:	Reduced blood pressure and produced a change in metabolites. Increased histidine levels after 1.5-3 h after administration.

Peso molecular

161.22

Fòrmula

C₆H₁₁NO₂S

No. CAS

52438-09-2

Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](CS/C=C/C)C(O)=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvente y solubilidad

In Vitro:

H₂O : 2.6 mg/mL (16.13 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.2027 mL	31.0135 mL	62.0270 mL
5 mM	1.2405 mL	6.2027 mL	12.4054 mL
10 mM	0.6203 mL	3.1014 mL	6.2027 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 5 mg/mL (31.01 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureza y Documentación

Purity: 99.91%

Select Batch:

Ficha de datos (276 KB) SDS (252 KB)

COA (244 KB) HNMR (478 KB) RP-HPLC (256 KB) LCMS (141 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Kodera Y, et al. Chemical and Biological Properties of S-1-Propenyl-l-Cysteine in Aged Garlic Extract. Molecules. 2017 Mar 31;22(4). [Content Brief]

[2]. Tsuneyoshi T, et al., S-1-Propenylcysteine augments BACH1 degradation and heme oxygenase 1 expression in a nitric oxide-dependent manner in endothelial cells. Nitric Oxide. 2019 Mar 1;84:22-29. [Content Brief]

[3]. Matsutomo T, et al., Metabolomic study reveals the acute hypotensive effect of S-1-propenylcysteine accompanied by alteration of the plasma histidine level in spontaneously hypertensive rats. J Pharm Biomed Anal. 2019 May 10;168:148-154. [Content Brief]

[4]. Suzuki JI, et al., Anti-inflammatory action of cysteine derivative S-1-propenylcysteine by inducing MyD88 degradation. Sci Rep. 2018 Sep 20;8(1):14148. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	6.2027 mL	31.0135 mL	62.0270 mL	155.0676 mL
	5 mM	1.2405 mL	6.2027 mL	12.4054 mL	31.0135 mL
	10 mM	0.6203 mL	3.1014 mL	6.2027 mL	15.5068 mL
	15 mM	0.4135 mL	2.0676 mL	4.1351 mL	10.3378 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.