S.pombe lumazine synthase-IN-1

Name: S.pombe lumazine synthase-IN-1
Brand: MedChemExpress
SKU: HY-44688
Rating: 4.5 (0 reviews)

製品番号: HY-44688 純度: 99.72%: Data Sheet SDS COA 取扱説明書
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S.pombe lumazine synthase-IN-1 is an inhibitor of lumazine synthases with K_i values of 243 μM and 9.6 μM for Schizosaccharomyces pombe and Mycobacterium tuberculosis lumazine synthases, respectively.

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S.pombe lumazine synthase-IN-1 構造式

CAS 番号 : 331726-35-3

容量	価格（税別）	在庫状況	数量

>無料サンプル (0.1 - 0.2 mg)		今すぐ申し込む
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 275	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 275	在庫あり	Estimated Time of Arrival: December 31
Solid
10 mg	$250	在庫あり	Estimated Time of Arrival: December 31
25 mg	$500	在庫あり	Estimated Time of Arrival: December 31
50 mg	$800	在庫あり	Estimated Time of Arrival: December 31
100 mg	$1280	在庫あり	Estimated Time of Arrival: December 31
500 mg	$3350	在庫あり	Estimated Time of Arrival: December 31
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* アイテムを追加する前、数量をご選択ください

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Based on 0 publication(s) in Google Scholar

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生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target

Ki: 243 μM (Schizosaccharomyces pombe lumazine synthase); 9.6 μM (Mycobacterium tuberculosis lumazine synthase)^[1]

体外実験

S.pombe lumazine synthase-IN-1 (Compound 21) is a class II compound with OCH3 groups displays slightly better potencies than its counterparts with OH groups^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

319.27

分子式

C₁₄H₁₃N₃O₆

CAS 番号

331726-35-3

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1NC(C([N+]([O-])=O)=C(/C=C/C2=CC=C(OC)C(OC)=C2)N1)=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 31.25 mg/mL (97.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1321 mL	15.6607 mL	31.3215 mL
5 mM	0.6264 mL	3.1321 mL	6.2643 mL
10 mM	0.3132 mL	1.5661 mL	3.1321 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.72%

Select Batch:

データシート (285 KB) SDS (251 KB)

COA (250 KB) HNMR (231 KB) LCMS (347 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Arindam Talukdar, et al. Discovery and Development of a Small Molecule Library With Lumazine Synthase Inhibitory Activity. J Org Chem. 2009 Aug 7;74(15):5123-34. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1321 mL	15.6607 mL	31.3215 mL	78.3036 mL
	5 mM	0.6264 mL	3.1321 mL	6.2643 mL	15.6607 mL
	10 mM	0.3132 mL	1.5661 mL	3.1321 mL	7.8304 mL
	15 mM	0.2088 mL	1.0440 mL	2.0881 mL	5.2202 mL
	20 mM	0.1566 mL	0.7830 mL	1.5661 mL	3.9152 mL
	25 mM	0.1253 mL	0.6264 mL	1.2529 mL	3.1321 mL
	30 mM	0.1044 mL	0.5220 mL	1.0440 mL	2.6101 mL
	40 mM	0.0783 mL	0.3915 mL	0.7830 mL	1.9576 mL
	50 mM	0.0626 mL	0.3132 mL	0.6264 mL	1.5661 mL
	60 mM	0.0522 mL	0.2610 mL	0.5220 mL	1.3051 mL
	80 mM	0.0392 mL	0.1958 mL	0.3915 mL	0.9788 mL