1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Saccharopine

Saccharopine (Synonyms: L-Saccharopine)

Cat. No.: HY-W040307
Handling Instructions

Saccharopine (L-Saccharopine), a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine by the lysine-ketoglutarate reductase. Saccharopine is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine impairs development by disrupting mitochondrial homeostasis.

For research use only. We do not sell to patients.

Saccharopine Chemical Structure

Saccharopine Chemical Structure

CAS No. : 997-68-2

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Description

Saccharopine (L-Saccharopine), a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine by the lysine-ketoglutarate reductase. Saccharopine is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine impairs development by disrupting mitochondrial homeostasis[1][2][3].

In Vitro

Saccharopine accumulation leads to mitochondrial damage and functional loss which is induced by saccharopine dehydrogenase (SDH) mutations of α-aminoadipate semialdehyde synthase (AASS)-1 in C. elegans[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Saccharopine accumulation induces mitochondrial damage and progressive postnatal growth retardation in Aass mutant mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

276.29

Formula

C11H20N2O6

CAS No.
SMILES

OC([[email protected]@H](NCCCC[[email protected]](N)C(O)=O)CCC(O)=O)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Saccharopine
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