Saccharopine hydrochloride
Based on 1 publication(s) in Google Scholar
Saccharopine (L-Saccharopine) hydrochloride, a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine hydrochloride by the lysine-ketoglutarate reductase. Saccharopine hydrochloride is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine hydrochloride impairs development by disrupting mitochondrial homeostasis.
For research use only. We do not sell to patients.
- Purity: 99.84%
- Formula: C11H21ClN2O6
- Molecular Weight:312.75
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Saccharopine hydrochloride
MoreAll Endogenous Metabolite Isoforms
More
Biological Activity
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Human Endogenous Metabolite |
Saccharopine accumulation leads to mitochondrial damage and functional loss which is induced by saccharopine dehydrogenase (SDH) mutations of α-aminoadipate semialdehyde synthase (AASS)-1 in C. elegans[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Oil
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Molecular Weight 312.75
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Formula C11H21ClN2O6
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Color Colorless to off-white
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SMILES
OC([C@H](CCC(O)=O)NCCCC[C@@H](C(O)=O)N)=O.[H]Cl
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Synonyms
L-Saccharopine hydrochloride
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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PLoS One
Lysine p-nitroanilide impairs cellular energetics and potentiates statin-induced cytotoxicity in RD rhabdomyosarcoma cells. [Abstract]2025 Dec 4;20(12):e0337895. PMID: 41343489
Solvent & Solubility
H2O : 175 mg/mL (559.55 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Zhou J, et, al. The lysine catabolite saccharopine impairs development by disrupting mitochondrial homeostasis. J Cell Biol. 2019 Feb 4;218(2):580-597. [Content Brief]
[2]. Leandro J, et, al. Saccharopine, a lysine degradation intermediate, is a mitochondrial toxin. J Cell Biol. 2019 Feb 4;218(2):391-392. [Content Brief]
[3]. Papes F, et, al. Lysine degradation through the saccharopine pathway in mammals: involvement of both bifunctional and monofunctional lysine-degrading enzymes in mouse. Biochem J. 1999 Dec 1;344 Pt 2(Pt 2):555-63. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.1974 mL | 15.9872 mL | 31.9744 mL | 79.9361 mL |
| 5 mM | 0.6395 mL | 3.1974 mL | 6.3949 mL | 15.9872 mL | |
| 10 mM | 0.3197 mL | 1.5987 mL | 3.1974 mL | 7.9936 mL | |
| 15 mM | 0.2132 mL | 1.0658 mL | 2.1316 mL | 5.3291 mL | |
| 20 mM | 0.1599 mL | 0.7994 mL | 1.5987 mL | 3.9968 mL | |
| 25 mM | 0.1279 mL | 0.6395 mL | 1.2790 mL | 3.1974 mL | |
| 30 mM | 0.1066 mL | 0.5329 mL | 1.0658 mL | 2.6645 mL | |
| 40 mM | 0.0799 mL | 0.3997 mL | 0.7994 mL | 1.9984 mL | |
| 50 mM | 0.0639 mL | 0.3197 mL | 0.6395 mL | 1.5987 mL | |
| 60 mM | 0.0533 mL | 0.2665 mL | 0.5329 mL | 1.3323 mL | |
| 80 mM | 0.0400 mL | 0.1998 mL | 0.3997 mL | 0.9992 mL | |
| 100 mM | 0.0320 mL | 0.1599 mL | 0.3197 mL | 0.7994 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Saccharopine hydrochloride Related Classifications
HY-W040307B Related Classifications
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