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Results for "

α2A-adrenoceptors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) Adrenergic Receptor (29) Apoptosis (8) Autophagy (7) Dopamine Receptor (2) Drug Metabolite (1) Histamine Receptor (2) Imidazoline Receptor (7) Isotope-Labeled Compounds (2) Reference Standards (7)
By Research Areas:	Cancer (9) Cardiovascular Disease (14) Endocrinology (7) Infection (1) Inflammation/Immunology (1) Neurological Disease (15)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103213

JP1302 dihydrochloride 2 Publications Verification	Adrenergic Receptor	Neurological Disease Endocrinology
JP1302 dihydrochloride is a potent, selective, high affinity antagonist of the *α_2C-adrenoceptor, with a K_b* of 16 nM and a K_i of 28 nM for the human α_2C-receptor. JP1302 dihydrochloride shows antidepressant and antipsychotic-like effects. JP1302 dihydrochloride can be used for neuropsychiatric disorders and renal dysfunction research ^[2] .

HY-100490

Rilmenidine	Imidazoline Receptor Adrenergic Receptor Apoptosis Autophagy	Cardiovascular Disease Cancer
Rilmenidine, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine is an *alpha 2-adrenoceptor* agonist. Rilmenidine induces autophagy. Rilmenidine acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na ⁺/H ⁺ antiport. Rilmenidine modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells ^[2] .

HY-109075A

Tasipimidine sulfate	Adrenergic Receptor	Neurological Disease
Tasipimidine sulfate is an orally active and selective *α_2A-adrenoceptor* agonist with a pEC₅₀ of 7.57 for human α_2A-adrenoceptors and an EC₅₀ of 5.7 nM for rat *α₂-adrenoceptor*. Tasipimidine sulfate can be utilized in research related to situational anxiety and fear ^[2].

HY-100490B

Rilmenidine phosphate	Imidazoline Receptor Adrenergic Receptor Apoptosis Autophagy	Cardiovascular Disease Cancer
Rilmenidine phosphate, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine phosphate is an *alpha 2-adrenoceptor* agonist. Rilmenidine phosphate induces autophagy. Rilmenidine phosphate acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na ⁺/H ⁺ antiport. Rilmenidine phosphate modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells ^[2] .

HY-203894

Carpipramine Defekton	Dopamine Receptor Adrenergic Receptor 5-HT Receptor	Neurological Disease
Carpipramine (Defekton) is an antipsychotic agent that belongs to the iminodibenzyl class. Carpipramine is a potent dopamine antagonist which blocks alpha 1- and *alpha 2-adrenoceptors. Carpipramine also has antagonist properties with respect to serotonin (5-ΗΤ2)* receptors. Carpipramine exhibits antipsychotic and anti-depressant effects. Carpipramine can be used for the research of neurological disease, such as post-traumatic stress disorder (PTSD) and depression .

HY-100490A

Rilmenidine hemifumarate	Imidazoline Receptor Adrenergic Receptor Apoptosis Autophagy	Cardiovascular Disease Cancer
Rilmenidine hemifumarate, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine hemifumarate is an *alpha 2-adrenoceptor* agonist. Rilmenidine hemifumarate induces autophagy. Rilmenidine hemifumarate acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na ⁺/H ⁺ antiport. Rilmenidine hemifumarate modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells ^[2] .

HY-101198

Clobenpropit dihydrobromide	Histamine Receptor Apoptosis	Neurological Disease Cancer
Clobenpropit dihydrobromide is a potent histamine H3R antagonist/inverse agonist with a pEC₅₀ of 8.07 for histamine H3LR . Clobenpropit dihydrobromide acts as partial agonist at histamine H4 receptors (K_i 13 nM). Clobenpropit dihydrobromide also binds to serotonin 5-HT3 receptors (K_i 7.4 nM) and α2A/α2C adrenoceptors (K_i 17.4/7.8 nM) ^[2]. Clobenpropit dihydrobromide increases apoptosis .

HY-103197

2-Methoxyidazoxan monohydrochloride RX821002 hydrochloride	Adrenergic Receptor	Neurological Disease
2-Methoxyidazoxan monohydrochloride (RX821002 hydrochloride) is a highly selective *alpha 2-adrenoceptor* antagonist with little or no imidazoline antagonist effect. RX 821002 has markedly higher affinity for (guinea-pig) alpha 2D-adrenoceptors (pK_d 9.7) than for (rabbit) alpha 2A-adrenoceptors (pK_d 8.2) ^[2].

HY-103213A

JP1302 2 Publications Verification	Adrenergic Receptor	Neurological Disease
JP1302 is a potent, selective, high affinity antagonist of the *α_2C-adrenoceptor, with a K_b* of 16 nM and a K_i of 28 nM for the human α_2C-receptor. JP1302 shows antidepressant and antipsychotic-like effects. JP1302 can be used for neuropsychiatric disorders and renal dysfunction research ^[2] .

HY-106769

Fluparoxan GR50360	Adrenergic Receptor	Neurological Disease
Fluparoxan is an orally active, selective and competitive *alpha 2-adrenoceptor* antagonist. Fluparoxan is an anti-depressant agent ^[2].

HY-103212A

Azepexole hydrochloride B-HT 933 hydrochloride; Oxazoloazepin hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Azepexole hydrochloride (B-HT 933 dihydrochloride; Oxazoloazepin dihydrochloride) is a selective agonist for *α 2-adrenoceptor, with pK_i* of 8.3, 7.6, and 7.5 for α2A-, α2B- and α2C-adrenoceptor subtypes, resepctively. Azepexole dihydrochloride causes concentration-dependent inhibition of peristaltic contractions with IC₅₀ of 78.72 nM. Azepexole hydrochloride exhibits antitussive and analgesic efficacy ^[2].

HY-101610

OPC-28326	Adrenergic Receptor	Cardiovascular Disease Endocrinology
OPC-28326 is a selective peripheral vasodilator and an angatonist of α2-adrenergic receptor, with K_i of 2040, 285, and 55 nM for α2A-, α2B- and α2C-adrenoceptors, respectively.

HY-N3298

Meranzin	Adrenergic Receptor	Cardiovascular Disease Neurological Disease
Meranzin is an absorbed bioactive compound from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS). Meranzin, isolated from leaves of Murraya exotica L., regulates the shared alpha 2-adrenoceptor and involves the AMPA-ERK1/2–BDNF signaling pathway. Meranzin has the potential for the prevention of the comorbidity of atherosclerosis and depression ^[2].

HY-B0371D

(S)-Terazosin	Adrenergic Receptor	Endocrinology
(S)-Terazosin is an active S-enantiomer of Terazosin. (S)-Terazosin is a potent and high-affinity *α-adrenoceptor* antagonist with K_i values of 3.91 nM, 0.79 nM and 1.16 nM for α1a, α1b and *α1d-adrenoceptor, respectively. (S)-Terazosin also has high-affinity for α2a, α2B* and *α2c*-adrenoceptor with K_i values of 729 nM, 3.5 nM and 46.4 nM, respectively .

HY-U00123A

Guanoxabenz hydrochloride Hydroxyguanabenz hydrochloride	Adrenergic Receptor	Neurological Disease
Guanoxabenz (Hydroxyguanabenz) hydrochloride is an α2 adrenergic receptor agonist, with a K_i of 4000 nM and the fully activated form 40 nM for an α2A adrenoceptor ^[2] .

HY-109075

Tasipimidine	Adrenergic Receptor	Neurological Disease
Tasipimidine is an orally active and selective *α_2A-adrenoceptor* agonist with a pEC₅₀ of 7.57 for human α_2A-adrenoceptors and an EC₅₀ of 5.7 nM for rat *α₂-adrenoceptor*. Tasipimidine can be utilized in research related to situational anxiety and fear ^[2].

HY-123514

SNAP8719 free base	Adrenergic Receptor Dopamine Receptor 5-HT Receptor	Others
SNAP8719 free base is a selective *α_1D-adrenoceptor* antagonist (pK_i = 8.89). SNAP8719 free base shows affinity for the dopamine D₂-, 5-HT_1A-, and the human clonal *α_2a-adrenoceptor, with pK_i* values of 5.98, 6.47, and <5.0, respectively. SNAP8719 free base causes a concentration-dependent increase in the twitch response .

HY-158194

α2C adrenoceptor agonist 1	Adrenergic Receptor	Cancer
α2C adrenoceptor agonist 1 (Compound A) is an orally active, highly selective, and non-central nervous system penetrating agonist for the *α2C-adrenoceptor, with EC₅₀* and K_i values of 108 nM and 12 nM, respectively. α2C adrenoceptor agonist 1 can be used in the study of nasal congestion .

HY-17416S

Guanfacine-d2 hydrochloride	Isotope-Labeled Compounds Adrenergic Receptor	Cardiovascular Disease Endocrinology
Guanfacine-d₂ (hydrochloride) is the deuterium labeled Guanfacine hydrochloride. Guanfacine hydrochloride, an anti-hypertensive agent, is a selective α2A-adrenoceptor agonist with Kd of 31 nM and displays 60-fold selectivity over α2B-adrenoceptors ^[2].

HY-103212

Azepexole dihydrochloride B-HT 933 dihydrochloride; Oxazoloazepin dihydrochloride	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Azepexole (B-HT 933) dihydrochloride is a potent and selective *alpha 2-adrenoceptor* agonist with pK_is of 8.3, 7.6, and 7.5 for α2A-, α2B- and α2C-adrenoceptor subtypes, resepctively . Azepexole dihydrochloride causes concentration-dependent inhibition of peristaltic contractions (IC₅₀= 78.72 nM) ^[2].

HY-106769C

Fluparoxan hydrochloride GR50360 hydrochloride	Adrenergic Receptor	Neurological Disease
Fluparoxan hydrochloride is an orally active, selective and competitive *alpha 2-adrenoceptor* antagonist. Fluparoxan hydrochloride is an anti-depressant agent ^[2].

HY-U00123

Guanoxabenz Hydroxyguanabenz	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Guanoxabenz is an α2 adrenergic receptor agonist, with a K_i of 4000 nM and the fully activated form 40 nM for an α2A adrenoceptor ^[2] .

HY-103216

RWJ52353	Adrenergic Receptor	Neurological Disease
RWJ52353 is a selective, orally active ligand for α2D adrenoceptor, which binds α2D, α2A, α2B and α1 receptors, with K_is of 1.5, 254, 621 and 443 nM. RWJ52353 exhibits analgesic efficacy in mouse abdominal irritation test (MAIT), with an ED₅₀ of 15.1 mg/kg .

HY-N3298R

Meranzin (Standard)	Reference Standards Adrenergic Receptor	Cardiovascular Disease Neurological Disease
Meranzin (Standard) is the analytical standard of Meranzin. This product is intended for research and analytical applications. Meranzin is an absorbed bioactive compound from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS). Meranzin, isolated from leaves of Murraya exotica L., regulates the shared alpha 2-adrenoceptor and involves the AMPA-ERK1/2–BDNF signaling pathway. Meranzin has the potential for the prevention of the comorbidity of atherosclerosis and depression ^[2].

HY-103213R

JP1302 dihydrochloride (Standard)	Reference Standards Adrenergic Receptor	Neurological Disease Endocrinology
JP1302 dihydrochloride (Standard) is the analytical standard of JP1302 dihydrochloride. This product is intended for research and analytical applications. JP1302 dihydrochloride is a potent, selective, high affinity antagonist of the α2C-adrenoceptor, with a Kb of 16 nM and a Ki of 28 nM for the human α2C-receptor. JP1302 dihydrochloride shows antidepressant and antipsychotic-like effects. JP1302 dihydrochloride can be used for neuropsychiatric disorders and renal dysfunction research ^[2] .

HY-100490S

Rilmenidine-d4	Isotope-Labeled Compounds Imidazoline Receptor Adrenergic Receptor Apoptosis Autophagy	Cardiovascular Disease Cancer
Rilmenidine-d₄ is the deuterium labeled Rilmenidine. Rilmenidine, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine is an alpha 2-adrenoceptor agonist. Rilmenidine induces autophagy. Rilmenidine acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells ^[2] .

HY-103197R

2-Methoxyidazoxan monohydrochloride (Standard) RX821002 hydrochloride (Standard)	Reference Standards Adrenergic Receptor	Neurological Disease
2-Methoxyidazoxan (monohydrochloride) (Standard) is the analytical standard of 2-Methoxyidazoxan (monohydrochloride). This product is intended for research and analytical applications. 2-Methoxyidazoxan monohydrochloride (RX821002 hydrochloride) is a highly selective alpha 2-adrenoceptor antagonist with little or no imidazoline antagonist effect. RX 821002 has markedly higher affinity for (guinea-pig) alpha 2D-adrenoceptors (pKd 9.7) than for (rabbit) alpha 2A-adrenoceptors (pKd 8.2) ^[2].

HY-136498AR

T-705RMP ammonium (Standard)	Reference Standards Drug Metabolite	Infection
Rilmenidine (phosphate) (Standard) is the analytical standard of Rilmenidine (phosphate). This product is intended for research and analytical applications. Rilmenidine phosphate, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine phosphate is an alpha 2-adrenoceptor agonist. Rilmenidine phosphate induces autophagy. Rilmenidine phosphate acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine phosphate modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells ^[2] .

HY-100490BR

Rilmenidine phosphate (Standard)	Reference Standards Imidazoline Receptor Adrenergic Receptor Apoptosis Autophagy	Cardiovascular Disease Cancer
Rilmenidine (phosphate) (Standard) is the analytical standard of Rilmenidine (phosphate). This product is intended for research and analytical applications. Rilmenidine phosphate, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine phosphate is an alpha 2-adrenoceptor agonist. Rilmenidine phosphate induces autophagy. Rilmenidine phosphate acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine phosphate modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells ^[2] .

HY-100490R

Rilmenidine (Standard)	Reference Standards Imidazoline Receptor Adrenergic Receptor Apoptosis Autophagy	Cardiovascular Disease Cancer
Rilmenidine (Standard) is the analytical standard of Rilmenidine. This product is intended for research and analytical applications. Rilmenidine, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine is an alpha 2-adrenoceptor agonist. Rilmenidine induces autophagy. Rilmenidine acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells ^[2] .

HY-100490AR

Rilmenidine hemifumarate (Standard)	Reference Standards Imidazoline Receptor Adrenergic Receptor Apoptosis Autophagy	Cardiovascular Disease Cancer
Rilmenidine (hemifumarate) (Standard) is the analytical standard of Rilmenidine (hemifumarate). This product is intended for research and analytical applications. Rilmenidine hemifumarate, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine hemifumarate is an alpha 2-adrenoceptor agonist. Rilmenidine hemifumarate induces autophagy. Rilmenidine hemifumarate acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine hemifumarate modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells ^[2] .

HY-182296

SCH 79687	Histamine Receptor	Inflammation/Immunology
SCH 79687 is an orally active histamine H3 receptor antagonist, with a K_i of 1.9 nM in rats and 13 nM in guinea pigs. SCH 79687 acts as a competitive antagonist against (R)-α-methylhistamine. SCH 79687 attenuates the inhibitory effect of (R)-α-methylhistamine-induced sympathetic hypertensive responses in guinea pigs. When used in combination with H1 antagonists, SCH 79687 inhibits Compound 48/80 (HY-115768)-induced nasal congestion in cats. SCH 79687 can be used for the research of allergic rhinitis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3298

Meranzin	Cardiovascular Disease other families Classification of Application Fields Neurological Disease Coumarins Phenylpropanoids Plants Disease Research Fields Source Classification	Adrenergic Receptor
Meranzin is an absorbed bioactive compound from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS). Meranzin, isolated from leaves of Murraya exotica L., regulates the shared alpha 2-adrenoceptor and involves the AMPA-ERK1/2–BDNF signaling pathway. Meranzin has the potential for the prevention of the comorbidity of atherosclerosis and depression ^[2].

HY-N3298R

Meranzin (Standard)	Structural Classification other families Coumarins Phenylpropanoids Plants Source Classification	Reference Standards Adrenergic Receptor
Meranzin (Standard) is the analytical standard of Meranzin. This product is intended for research and analytical applications. Meranzin is an absorbed bioactive compound from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS). Meranzin, isolated from leaves of Murraya exotica L., regulates the shared alpha 2-adrenoceptor and involves the AMPA-ERK1/2–BDNF signaling pathway. Meranzin has the potential for the prevention of the comorbidity of atherosclerosis and depression ^[2].

Cat. No.	Product Name	Chemical Structure

HY-17416S

Guanfacine-d2 hydrochloride
Guanfacine-d₂ (hydrochloride) is the deuterium labeled Guanfacine hydrochloride. Guanfacine hydrochloride, an anti-hypertensive agent, is a selective α2A-adrenoceptor agonist with Kd of 31 nM and displays 60-fold selectivity over α2B-adrenoceptors ^[2].

HY-100490S

Rilmenidine-d4
Rilmenidine-d₄ is the deuterium labeled Rilmenidine. Rilmenidine, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine is an alpha 2-adrenoceptor agonist. Rilmenidine induces autophagy. Rilmenidine acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells ^[2] .

Rilmenidine-d4

Rilmenidine-d₄ is the deuterium labeled Rilmenidine. Rilmenidine, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine is an alpha 2-adrenoceptor agonist. Rilmenidine induces autophagy. Rilmenidine acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells ^[2] .

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