RWJ52353
RWJ52353 is a selective, orally active ligand for α2D adrenoceptor, which binds α2D, α2A, α2B and α1 receptors, with Kis of 1.5, 254, 621 and 443 nM. RWJ52353 exhibits analgesic efficacy in mouse abdominal irritation test (MAIT), with an ED50 of 15.1 mg/kg.
For research use only. We do not sell to patients.
- CAS No.: 245744-10-9
- Formula: C11H10N2S
- Molecular Weight:202.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Adrenergic Receptor Isoforms
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Biological Activity
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Alpha-2D adrenergic receptor 1.5 nM (Ki) |
Alpha-2A adrenergic receptor 254 nM (Ki) |
α1-adrenergic receptor 443 nM (Ki) |
Alpha-2B adrenergic receptor 621 nM (Ki) |
Chemical Information
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CAS No. 245744-10-9
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Molecular Weight 202.28
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Formula C11H10N2S
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SMILES
C1(C2=CCCC3=C2C=CS3)=CN=CN1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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