2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor Dopamine Receptor 5-HT Receptor
  4. SNAP8719 free base

SNAP8719 free base is a selective α1D-adrenoceptor antagonist (pKi = 8.89). SNAP8719 free base shows affinity for the dopamine D2-, 5-HT1A-, and the human clonal α2a-adrenoceptor, with pKi values of 5.98, 6.47, and <5.0, respectively. SNAP8719 free base causes a concentration-dependent increase in the twitch response.

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SNAP8719 free base

SNAP8719 free base Chemical Structure

CAS No. : 255893-38-0

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SNAP8719 free base Related Antibodies

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α adrenergic receptor β adrenergic receptor

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Description

SNAP8719 free base is a selective α1D-adrenoceptor antagonist (pKi = 8.89). SNAP8719 free base shows affinity for the dopamine D2-, 5-HT1A-, and the human clonal α2a-adrenoceptor, with pKi values of 5.98, 6.47, and <5.0, respectively. SNAP8719 free base causes a concentration-dependent increase in the twitch response[1].

IC50 & Target[1]

Alpha-1D adrenergic receptor

8.89 (pKi)

D2 Receptor

5.98 (pKi)

5-HT1A Receptor

6.47 (pKi)

Alpha-2A adrenergic receptor

<5.0 (pKi)

Molecular Weight

423.47

Formula

C22H28F3N3O2
CAS No.
SMILES

O=C(N([C@H](C)CN1CCN(C2=CC(F)=C(F)C=C2F)CC1)C(C3)=O)CC43CCCC4
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SNAP8719 free base Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SNAP8719255893-38-0SNAP 8719SNAP-8719Adrenergic ReceptorDopamine Receptor5-HT ReceptorBeta ReceptorSerotonin Receptor5-hydroxytryptamine Receptortwitch responseInhibitorinhibitorinhibit

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